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About the Role

As a Member of Technical Staff focused on statistical genetics, you will help turn genetic association data into a rigorous substrate for biological foundation models. You will work with diverse data streams from GWAS, QTLs, variant annotation, biobank-scale phenotypes, and functional genomics to ask whether models understand the structure of genetic variation and its relationship to molecular and organismal traits. This role is part data architect, part methods scientist, and part model evaluator, collaborating closely with AI engineers and computational biologists to design datasets, benchmarks, and analyses.

Responsibilities

Build and evaluate large-scale statistical genetics resources for model training and assessment, including GWAS summary statistics, QTL maps, fine-mapping results, variant annotations, haplotypes, population reference panels, and biobank-scale phenotype data.
Design benchmarks that test whether models capture genetic architecture: linkage disequilibrium, ancestry, constraint, polygenicity, pleiotropy, regulatory effects, rare variant burden, and cross-population generalization.
Partner with AI/ML engineers to analyze model behavior on variant effect prediction, disease association, genotype-to-phenotype prediction, and regulatory region interpretation.
Develop practical standards for genetic data provenance, QC, leakage prevention, population bias assessment, privacy, consent, and responsible use of human genetic data.

Requirements

PhD in statistical genetics, human genetics, computational biology, biostatistics, or a related field, OR substantial industry experience working with population-scale genetic data.
Deep working knowledge of concepts and methods in statistical genetics: GWAS, LD, ancestry/population structure, heritability, fine-mapping, QTL mapping, rare variant analysis, polygenic risk, and variant annotation.
Experience with large genetic resources such as UK Biobank, All of Us, TOPMed, gnomAD, GTEx, FinnGen, ENCODE, or similar datasets.
Strong Python or R programming skills and experience building reliable, reproducible scientific analyses or software.
Experience working with agentic coding tools.
Clear communicator who can bridge scientific context with engineering teams and partner organizations.
Curiosity and resilience when tackling open-ended scientific challenges.

Skills

Statistical genetics
Human genetics
Computational biology
Biostatistics
Population-scale genetic data
GWAS
LD
Ancestry/population structure
Heritability
Fine-mapping
QTL mapping
Rare variant analysis
Polygenic risk
Variant annotation
Python
R
Agentic coding tools
Polygenic risk score methods
ML for genomics
Sequence models
Variant effect predictors
Regulatory models
Multimodal models
Biological foundation models
Colocalization
Mendelian randomization
TWAS
Causal inference
Cross-ancestry genetics
Admixed populations
Privacy-preserving genomic analysis
Reproducible pipelines
Shared resources
Open datasets
Benchmarking frameworks

Experience Level

PhD or substantial industry experience

Education Level

Benefits

Competitive compensation
Comprehensive benefits
Support for continual learning

About the Company

Radical Numerics is an AI research lab building general biological intelligence.
Our mission is to master the code of life, and our purpose is to reduce human suffering.
Our team created Evo, and started the field of generative genomics.
Our work was featured on the cover of Science, and presented by our CEO on the main stage of TED2025.
Evo was used to create the first AI-generated CRISPR-Cas9, and the first AI whole genome from scratch.
Evo 2, featured in Nature, is the largest fully open source AI project across any domain.
In October, we introduced Omnii-1, the world's most advanced multimodal genome language model, and a leap toward general biological intelligence.
It unifies 28 biological modalities, spanning DNA, RNA, proteins, epigenomics, and more, in a single model trained on trillions of tokens of biological data.
In a world first, Omnii-1 designed the first AI-generated bacteriophages to be administered to a human patient with an antibiotic-resistant infection under compassionate use.
We released this news alongside seven other project areas, showing the model’s breadth of applications.
The same generative breakthroughs that enable life-saving cures also lowers the barrier to creating engineered threats and AI-generated bioweapons.
We believe these forces are inseparable.
Radical Numerics was founded to develop both the power to design and the responsibility to defend.

Equal Opportunity

Radical Numerics is committed to equal employment opportunity and does not discriminate in any employment opportunities or practices based on an individual's race, color, creed, gender (including gender identity and gender expression), religion (all aspects of religious beliefs, observance or practice, including religious dress or grooming practices), marital status, registered domestic partner status, age, national origin or ancestry (including language use restrictions and possession of a driver’s license issued under California Vehicle Code section 12801.9), natural hair, physical or mental disability, political affiliation, medical condition (including cancer or a record or history of cancer, and genetic characteristics), sex (including pregnancy, childbirth, breastfeeding or related medical condition), genetic information, sexual orientation, military and veteran status or any other consideration made unlawful by federal, state, or local laws.
It also prohibits unlawful discrimination based on the perception that anyone has any of those characteristics, or is associated with a person who has or is perceived as having any of those characteristics.
Radical Numerics participates in E-Verify and will provide the federal government with your Form I-9 information to confirm that you are authorized to work in the U.S.