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About the Role
Pliant is seeking a PhD organic chemist for a 9-month contract to write the experimental sections of patent applications. This desk-based role involves transforming completed synthetic work into accurate, patent-ready procedures and characterization data, working closely with medicinal chemists and patent counsel.
Responsibilities
- Write clear, reproducible experimental procedures for intermediates and final compounds, in patent format, from ELN entries and the original chemists’ notes.
- Draft general procedures and synthetic schemes, and map each example to the correct general method.
- Compile and verify characterization data (¹H/¹³C NMR, LCMS, HRMS, chiral HPLC) and write data strings in a consistent format.
- Check every structure against its data: confirm that NMR assignments, masses and stereochemistry match the drawn compound, and flag any discrepancies.
- Generate and check chemical names (e.g., IUPAC names using ChemDraw), and keep compound, example and intermediate numbering consistent throughout each application.
- Build and maintain compound tables, cross-referenced to internal compound IDs, ELN references and biological data tables.
- Track every example’s status (data complete, under review, final) across multiple applications, and keep an audit trail of changes.
- Work with medicinal chemists to resolve gaps or inconsistencies in the records, and with patent counsel to meet drafting and filing deadlines.
- Handle all compound and invention information under strict confidentiality.
Requirements
- PhD in Organic Chemistry or a closely related field, with 0–2 years of postdoctoral or industry experience.
- Demonstrated experience writing experimental procedures and characterization data, for example in a dissertation, supporting information for publications, or patent applications.
- Strong ability to interpret ¹H and ¹³C NMR, LCMS and HRMS data and confirm that it is consistent with a proposed structure, including stereochemistry.
- Working knowledge of multistep synthesis and common reaction types, sufficient to spot errors in reagents, equivalents, yields or workups.
- Proficiency with ChemDraw (structures, schemes and naming), Microsoft Word and Excel.
- Exceptional attention to detail: able to check large volumes of data for consistency without losing accuracy.
- Strong organizational skills: able to track hundreds of compounds across several documents and deadlines.
- Proactive communicator who raises gaps early and asks chemists precise, easy-to-answer questions.
- Prior experience preparing experimental sections or examples for composition-of-matter patent applications.
- Medicinal chemistry experience, ideally with heterocyclic, peptidomimetic or other drug-like small molecules.
- Familiarity with patent structure and terms (examples, general procedures, Markush structures, claims) and the importance of written description and enablement.
- Experience with ELN and chemistry informatics tools (e.g., Scilligence, D360, ChemDraw/ChemOffice).
- Experience organizing large data sets in Excel, including lookups and data validation.
Skills
- Organic Chemistry
- Patent Writing
- Experimental Procedures
- Characterization Data
- NMR Interpretation
- LCMS Interpretation
- HRMS Interpretation
- Chiral HPLC
- Multistep Synthesis
- ChemDraw
- Microsoft Word
- Microsoft Excel
- Attention to Detail
- Organizational Skills
- Communication
- ELN
- Chemistry Informatics Tools
- Scilligence
- D360
- ChemOffice
Location
- South San Francisco
Work Type
- Contract
- Hybrid
- Full-time
Experience Level
- 0-2 years postdoctoral or industry experience
Education Level
- PhD in Organic Chemistry
Salary/Compensations
- $68/hr – $75/hr
About the Company
- At Pliant, we believe differentiated science can make a meaningful impact.
- We see our success as a direct result of the central role that each team member plays in advancing our mission to develop therapies that target the disease at its source.
- We are seeking creative, curious and collaborative individuals who dare to succeed, are committed to making an important impact on patient’s lives and will help us build one Pliant!
Equal Opportunity
- To understand how Pliant complies with and manages your personal information with respect to the California Consumer Privacy Act, please visit https://pliantrx.com/ccpa-applicant-and-staff-privacy-notice/.