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About the Role

Join Regeneron's Analytical and Biological Mass Spectrometry (ABMS) team to support R&D programs. You will work in a collaborative mass spectrometry laboratory focused on the biochemical characterization of emerging therapeutic modalities and monoclonal antibodies across all stages of development. This position offers an opportunity to contribute to a fast-growing, science-driven organization while learning through hands-on project work and making a meaningful difference for patients worldwide.

Responsibilities

Develop and optimize primarily LC-MS-based analytical methods to support diverse R&D programs, applying sound scientific judgment and demonstrating a clear understanding of the methods and experiments performed.
Analyze and interpret LC-MS data using appropriate software and bioinformatics tools to characterize the quality attributes of therapeutic proteins and emerging modalities.
Support R&D activities and regulatory submissions while expanding organizational knowledge of antibody therapeutics and other emerging modalities.
Independently perform sample preparation and LC-MS-based experiments according to SOPs, and document experiments, results, and conclusions in electronic laboratory notebook (ELN) entries.
Present data at group and project meetings, and prepare technical reports, SOPs, and regulatory submission documents.
Summarize results clearly and concisely using graphs, figures, and tables to support presentations, peer-reviewed publications, and regulatory documents.
Communicate with integrity, honesty, and respect in written and verbal interactions; contribute openly to scientific discussions and raise questions or concerns when appropriate.
Take ownership of experimental work, openly discuss unexpected results, identify root causes, and make timely corrections while maintaining accurate and transparent records.
Learn new technologies and scientific concepts through active participation in projects, collaboration with colleagues, and constructive feedback, while contributing enthusiastically in a team environment.

Requirements

BS or MS (or higher) in chemistry, biochemistry, analytical chemistry, pharmaceutical sciences, metabolism, or a related field.
6–8+ years of industrial or academic experience in the analytical characterization of small molecules, antibodies, protein therapeutics, AAVs, metabolites, lipids, or other therapeutic modalities.
Knowledge of and hands-on experience with LC-MS-based sample preparation for cells, tissues, biological matrices, and drug substances.
Strong knowledge of metabolism and hands-on experience in metabolomics or lipidomics are highly desirable; experience with metabolic flux analysis, isotope tracing, or related quantitative approaches is a plus.
Knowledge of pharmaceutical formulation and process development is a plus.
Knowledge of and experience in AAV virology, siRNA, and structural biology are a plus.
Experience with automated liquid-handling systems (Biomek, Bravo, KingFisher, Tecan, or similar platforms) is a plus.
Experience with specialized LC-MS-based techniques, such as hydrogen-deuterium exchange mass spectrometry (HDX-MS), ion mobility spectrometry-mass spectrometry (IMS-MS), and quantitative proteomics, is a plus.
Experience with experimental design and data analysis, including design of experiments (DoE), molecular modeling, graphing, statistical analysis, or quantitative pathway and flux analysis software, is a plus.

Skills

LC-MS-based analytical methods
LC-MS data analysis
Bioinformatics tools
Biochemical characterization
Therapeutic protein characterization
Monoclonal antibody characterization
Sample preparation
Electronic laboratory notebook (ELN) documentation
Technical report writing
SOP development
Regulatory submission documentation
Metabolism
Metabolomics
Lipidomics
Metabolic flux analysis
Isotope tracing
Quantitative approaches
Pharmaceutical formulation
Process development
AAV virology
siRNA
Structural biology
Automated liquid-handling systems
HDX-MS
IMS-MS
Quantitative proteomics
Experimental design
Data analysis
Design of experiments (DoE)
Molecular modeling
Graphing
Statistical analysis
Quantitative pathway analysis
Flux analysis software

Location

Tarrytown, NY

Work Type

Full-time
Onsite (minimum four days per week)

Experience Level

6-8+ years of industrial or academic experience

Education Level

BS or MS (or higher) in chemistry, biochemistry, analytical chemistry, pharmaceutical sciences, metabolism, or a related field

Salary/Compensations

$93,900.00 - $153,300.00

Benefits

Annual bonuses or other incentive plans
Equity awards
Pension or retirement benefits
401(k) company match
Health and wellness programs
Fitness centers
Insurance benefits (e.g. medical, dental, vision, life and disability)
Paid time off
Family support benefits

About the Company

Regeneron uses science and innovation to develop life-changing medicines for people with serious diseases.
We are committed to building a workplace with an inclusive culture.
We believe we do our best work when we are together.

Equal Opportunity

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law.
Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.