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About the Role
Contribute to the development and optimization of CMOS chip-based phosphoramidite DNA synthesis workflows, focusing on improving synthesis efficiency and fidelity through protocol development and failure-mode analysis.
Responsibilities
- Contribute to the development and optimization of CMOS chip-based phosphoramidite DNA synthesis workflows.
- Develop and optimize electrochemical DNA synthesis protocols, including chip handling, hardware configuration and software integration, and chemistry process.
- Execute rigorous failure-mode analysis to systematically identify, diagnose, and resolve multi-variable root causes.
- Collaborate with engineering and synthesis teams to build and iterate prototype testbeds.
- Operate NGS-based analytical pipelines for quality assessment of oligonucleotide pools.
- Analyze experimental data using molecular biology and organic chemistry techniques.
- Drive technology transfers from R&D to manufacturing, ensuring robust scale-up and process documentation.
- Define and execute scientific and technical objectives aligned with company goals.
- Present experimental plans, results, conclusions, and next steps.
- Maintain detailed and meticulous records of all experimental work and analysis.
Requirements
- Advanced degree (PhD or Master) in Chemistry, Organic Chemistry, Chemical Engineering, or a closely related field.
- Minimum 2 years of biotech or pharma R&D experience (Doctoral degree) or minimum 5 years of experience (Master's degree).
- Proven track record and proficiency in phosphoramidite oligonucleotide synthesis chemistry and platform development.
- Experience in oligonucleotide microarray or pool synthesis is highly desirable.
- Hands-on experience with NGS workflows and data analysis is highly desirable.
- Strong understanding of DNA chip technologies and electrochemistry is highly desirable.
- Demonstrated ability to participate in cross-functional projects and collaborate across R&D and manufacturing teams.
- Excellent problem-solving, communication, and project management skills.
- Must be able to move about the laboratory and office environment regularly.
- Must have fine motor skills and steady hands to handle delicate instruments, operate laboratory equipment, pipette accurately, and perform repetitive benchwork with precision.
- Must be able to lift and carry up to 40 pounds occasionally.
- Must have sufficient visual acuity to read small print on labels, instrument displays, and computer monitors.
- Frequently exposed to typical laboratory conditions, including biological samples, chemicals, and reagents.
- Must be able to wear appropriate personal protective equipment (PPE) such as lab coats, gloves, and safety goggles as required.
Skills
- Phosphoramidite oligonucleotide synthesis chemistry
- Platform development
- Oligonucleotide microarray synthesis
- Oligonucleotide pool synthesis
- NGS workflows
- NGS data analysis
- DNA chip technologies
- Electrochemistry
- Problem-solving
- Communication
- Project management
- Molecular biology techniques
- Organic chemistry techniques
Location
- South San Francisco
Work Type
- Onsite
- Laboratory
- Office
Experience Level
- Minimum 2 years of biotech or pharma R&D experience (Doctoral degree)
- Minimum 5 years of experience (Master's degree)
Education Level
- PhD
- Master's degree