Associate Principal Scientist, Automation & Screening (Biologics Discovery)
Merck · CA, US
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About the Role
We are seeking an innovative scientific leader to develop and advance automated workflows for antibody discovery and characterization. The Associate Principal Scientist will combine automation and bioassay expertise with strategic and operational leadership, manage a small team of scientists, establish priorities, and support team development while delivering robust, scalable, and decision enabling capabilities.
Responsibilities
- Develop and advance automated workflows for antibody discovery and characterization.
- Combine automation and bioassay expertise with strategic and operational leadership.
- Manage a small team of scientists.
- Establish priorities and support team development.
- Deliver robust, scalable, and decision enabling capabilities.
- Direct complex laboratory automation or high throughput screening activities across multiple programs.
- Program, configure, and troubleshoot automated liquid handling platforms.
- Process data, automate workflows, or integrate instruments using Python, SQL, R, or related tools.
- Translate scientific needs into scalable workflows.
- Define experimental plans.
- Resolve complex technical issues.
- Manage priorities and resources across concurrent biotherapeutic discovery workstreams.
- Supervise a small team of automation scientists, including coaching, performance feedback, and professional development.
- Train laboratory users.
- Standardize automated methods.
- Oversee safe and compliant laboratory operations.
- Evaluate or implement innovative antibody discovery technologies.
- Contribute to publications, intellectual property, technology strategy, or external collaborations.
Requirements
- Bachelor's (with 10+ years), Master's (with 6+ years) or Ph.D. (with 4+ years) in a relevant biological science or related field and relevant experience.
- Demonstrated scientific leadership directing complex laboratory automation or high throughput screening activities across multiple programs.
- Hands on experience with automated liquid handling platforms, such as the Hamilton Microlab STAR, robotic arms, and related automation software, including method programming, configuration, and troubleshooting.
- Experience with Python, SQL, R, or related tools for data processing, workflow automation, or instrument integration.
- Strong experience with binding and cell-based assays, including ELISA and flow cytometry or fluorescence activated cell sorting.
- Ability to translate scientific needs into scalable workflows, define experimental plans, resolve complex technical issues, and manage priorities and resources across concurrent biotherapeutic discovery workstreams.
- Prior experience managing or supervising a small team of automation scientists, including coaching, performance feedback, and professional development.
- Excellent communication, collaboration, and influencing skills in a matrixed research organization.
- Experience training laboratory users, standardizing automated methods, and overseeing safe and compliant laboratory operations.
- Experience evaluating or implementing innovative antibody discovery technologies, such as microfluidics, genetic or messenger RNA immunization, single cell screening, or other high throughput approaches.
- Strong knowledge of antibody discovery, characterization, NGS, protein engineering, and biologics modality design.
- Contributions to publications, intellectual property, technology strategy, or external collaborations.
Skills
- Antibodies
- Antibody Discovery
- Automation
- Cell-Based Assays
- ELISA Techniques
- Flow Cytometry
- Laboratory Automation
- Laboratory Robotics
- Laboratory Techniques
- Liquid Handling
- People Management
- Robotic Liquid Handlers
- Team Supervision
- Python
- SQL
- R
- Binding Assays
- ELISA
- Fluorescence Activated Cell Sorting
- Microfluidics
- Genetic Immunization
- Messenger RNA Immunization
- Single Cell Screening
- High Throughput Screening
- NGS
- Protein Engineering
- Biologics Modality Design
- Communication
- Collaboration
- Influencing Skills
Location
- USA - California - South San Francisco (Grand Ave)
Work Type
- Regular
- Domestic/International Relocation
- VISA Sponsorship
- 1st - Day Shift
Experience Level
- Associate Principal Scientist
- 10+ years (with Bachelor's)
- 6+ years (with Master's)
- 4+ years (with Ph.D.)
Education Level
- Bachelor's Degree
- Master's Degree
- Ph.D.
Salary/Compensations
- $159,600.00 - $251,200.00
Benefits
- Medical
- Dental
- Vision healthcare
- Other insurance benefits (for employee and family)
- Retirement benefits, including 401(k)
- Paid holidays
- Vacation
- Compassionate and sick days
About the Company
- Antibody Generation within Discovery Biologics delivers differentiated therapeutic antibodies through innovative discovery, screening, and characterization approaches.
- We collaborate across protein sciences, data sciences, engineering, and therapeutic area teams to advance programs from early discovery through candidate selection.
- We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds.
- The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment.
- We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.
Equal Opportunity
- As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.
- As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.
- We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.
- Learn more about your rights, including under California, Colorado and other US State Acts