Principal Scientist, Integrated Computational and Experimental Inflammation Discovery
Amgen · CA, US
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About the Role
Join Amgen's mission to serve patients living with serious illnesses by pioneering biotech and advancing a pipeline of innovative medicines. This role combines experimental and computational strategies to accelerate discovery and development of novel therapies, utilizing wet-lab biology and AI/ML-driven approaches for human-data-driven understanding of disease mechanisms.
Responsibilities
- Continuously apply computational, agentic and other AI-driven approaches to generate mechanistic insights, refine therapeutic hypotheses, and guide experimental design.
- Design, execute, analyze, and interpret studies to investigate disease mechanisms and test therapeutic hypotheses.
- Generate high-quality experimental data to support target identification, validation, and progression of Inflammation research programs.
- Integrate experimental findings with published literature, human genetics, clinical observations, and other data sources to develop mechanistic insights and inform scientific decision-making.
- Participate in scientific discussions, target reviews, and portfolio evaluations by contributing data-driven insights and recommendations.
- Present scientific findings and recommendations to project teams, governance forums, and departmental meetings.
- Maintain accurate documentation and contribute to organizational knowledge-sharing efforts.
- Embrace and contribute to a culture of scientific curiosity, collaboration, continuous learning, and operational excellence.
Requirements
- Doctorate degree PhD, PharmD, or MD with relevant post-doc and 2 years of Industry experience in Inflammation/Immunology research.
- Master’s degree and 5 years of Industry experience in Inflammation/Immunology research.
- Bachelor’s degree and 7 years of Industry experience in Inflammation/Immunology research.
- Experience working effectively within highly collaborative and matrixed research environments.
- Ability to balance scientific rigor with urgency and adaptability in a dynamic research environment.
- Demonstrated commitment to teamwork, knowledge sharing, and continuous improvement.
Skills
- Wet-lab biology
- AI/ML-driven computational research
- Agentic research approaches
- Human-data-driven understanding of disease mechanisms
- Scientific discussions
- Target reviews
- Portfolio evaluations
- Data-driven insights
- Scientific findings presentation
- Organizational knowledge-sharing
Location
- U.S. (excluding Puerto Rico)
Work Type
- Flexible work models where possible
Experience Level
- 2 years of Industry experience in Inflammation/Immunology research (with Doctorate)
- 5 years of Industry experience in Inflammation/Immunology research (with Master's)
- 7 years of Industry experience in Inflammation/Immunology research (with Bachelor's)
Education Level
- Doctorate degree (PhD, PharmD, or MD)
- Master’s degree
- Bachelor’s degree
Salary/Compensations
- 163,790.75USD -221,599.25 USD
Benefits
- Comprehensive employee benefits package
- Retirement and Savings Plan with generous company contributions
- Group medical, dental and vision coverage
- Life and disability insurance
- Flexible spending accounts
- Discretionary annual bonus program
- Stock-based long-term incentives
- Award-winning time-off plans
About the Company
- Since 1980, Amgen has pioneered the biotech industry, focusing on Oncology, Inflammation, General Medicine, and Rare Disease.
- Amgen is advancing a broad pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity.
- Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values.
- Together, we compete in the fight against serious disease.
Equal Opportunity
- Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.
- We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.
- Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.