Sr Assoc Scientist, Intact Mass (Analytical and Biological Mass Spectrometry)
Regeneron Pharmaceuticals · NY, US
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About the Role
Develop and apply LC-MS-based analytical methods to advance Regeneron’s pipeline across all stages of development, including antibodies, antibody-drug conjugates (ADCs), and other emerging modalities. This role focuses on characterizing therapeutic protein candidates, with an emphasis on critical quality attributes and process development, while collaborating with cross-functional teams.
Responsibilities
- Develop and apply LC-MS-based analytical methods to characterize mAbs and other therapeutic protein candidates across R&D programs
- Perform sample preparation, LC-MS experiments, and data analysis using relevant software and bioinformatics tools to characterize product quality attributes
- Document results in electronic laboratory notebook (ELN) entries, presentations, and reports
- Support process development, R&D activities, and regulatory submissions through analytical characterization and scientific problem-solving
- Collaborate with cross-functional teams to understand analytical needs, coordinate samples and study activities, and align priorities, timelines, and deliverables
- Interpret and communicate scientific results through project and group meetings, technical reports, regulatory documents, internal and external conferences, and peer-reviewed publications
- Plan and prioritize work, manage and visualize data, and deliver clear, timely updates
Requirements
- Master’s degree with at least 3 years of relevant experience, or a Bachelor’s degree with at least 6 years of relevant experience, in Chemistry, Biochemistry, Analytical Chemistry, Pharmaceutical Sciences, or a related field
- Industrial or academic experience in analytical characterization of protein therapeutics, bioconjugates, or other therapeutic modalities
- Strong knowledge of and hands-on experience with LC-MS-based characterization of proteins, peptides, and antibody-drug conjugates, including sample preparation, liquid chromatography, mass spectrometry, and data analysis
- Enjoy developing and troubleshooting analytical methods and solving complex scientific and technical problems
Skills
- LC-MS-based analytical methods
- Mass spectrometry
- Liquid chromatography
- Data analysis
- Sample preparation
- Bioinformatics tools
- Scientific problem-solving
- Advanced mass spectrometer platforms (e.g., Orbitrap, Q-TOF, and triple quadrupole)
- Relevant data processing software (e.g., Xcalibur, Protein Metrics, ChemDraw, Skyline, Proteome Discoverer)
Location
- Tarrytown, NY
Work Type
- Full-time
- On-site
Experience Level
- Sr. Associate Scientist
Education Level
- Master's degree
- Bachelor's degree
Salary/Compensations
- $80,300.00 - $131,100.00
Benefits
- Student Loan Paydown program & Tuition Reimbursement
- Family Care Benefits
- Relocation Assistance
- Inclusion, Culture and Well-Being programs (including physical & mental health)
- Annual bonuses or other incentive plans
- Equity awards
- Pension or retirement benefits
- 401(k) company match
- Health and wellness programs
- Fitness centers
- Insurance benefits (e.g. medical, dental, vision, life and disability)
- Paid time off
About the Company
- Regeneron uses science and innovation to develop life-changing medicines for people with serious diseases.
- This is a fast-growing, science-driven organization that is making a meaningful difference for patients worldwide.
- We believe we do our best work when we are together.
Equal Opportunity
- Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law.
- Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.