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About the Role
The Biologics Production Scientist will produce, purify, and QC proteins and reagents essential for the Portal platform and R&D projects. This role involves optimizing, automating, and scaling production processes, with a focus on producing high-quality biological materials reliably and improving manufacturing methods.
Responsibilities
- Produce and purify recombinant proteins using bacterial, cell-free, and other expression systems.
- Prepare buffers and reagents to defined specifications and assist in validating automated preparation.
- Supply R&D projects with proteins and reagents, managing requests, specifications, and timelines.
- Optimize and scale production processes for proteins, buffers, and reagents to enhance yield, purity, consistency, and turnaround time.
- Troubleshoot production issues systematically and utilize data for process improvements.
- Balance platform supply and R&D priorities, collaborating with cross-functional teams.
- Perform QC and release testing on proteins and buffers, including SDS-PAGE, concentration, purity, and activity assays.
- Complete batch records, maintain traceability, and support lot release within the eQMS.
- Write and maintain SOPs, Work Instructions, and specifications.
- Contribute to deviation management, CAPA, and change control processes.
Requirements
- BSc, MSc, or equivalent industry experience in biochemistry, molecular biology, bio-engineering, biotechnology, or a related discipline.
- Hands-on experience expressing and purifying recombinant proteins, preferably including E. coli systems.
- Experience with chromatographic purification techniques (e.g., FPLC/ÄKTA, affinity, ion exchange, size exclusion).
- Experience with QC or analytical characterization of proteins and reagents.
- Experience working within a QMS with documented procedures and meticulous record-keeping.
- Proven ability to troubleshoot and improve the robustness, yield, or reproducibility of laboratory processes.
- Strong organizational and communication skills.
- Ability to balance competing priorities and collaborate effectively with internal customers.
Skills
- Protein expression
- Protein purification
- Chromatographic purification
- Quality Control (QC)
- Analytical characterization
- Biochemistry
- Molecular biology
- Bio-engineering
- Biotechnology
- Process optimization
- Process scale-up
- Troubleshooting
- Documentation
- Record-keeping
- SOP writing
- QMS
- E. coli expression systems
- Cell-free expression
- FPLC/ÄKTA
- Affinity chromatography
- Ion exchange chromatography
- Size exclusion chromatography
- SDS-PAGE
- Activity assays
Location
- Scale Space, White City, London
Work Type
- Full-time
- Onsite
Experience Level
- Mid-level
Education Level
- BSc
- MSc
About the Company
- Portal is an equal opportunities employer committed to creating and sustaining an inclusive and equitable environment for all.
Equal Opportunity
- Portal is an equal opportunities employer. We are enriched by our diversity and are committed to creating and sustaining an inclusive and equitable environment for all. We encourage applications from candidates of all backgrounds and life experiences.
- If you require any reasonable adjustments during the recruitment process, please let us know.