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About the Role
As a Research Associate, you will work alongside scientists to understand and engineer how protein systems assemble. Through experiments in biochemistry and cell biology, you will investigate protein interactions, activity, and structure, with opportunities to take increasing ownership of experimental design and interpretation.
Responsibilities
- Design and execute assays to uncover how protein complexes assemble in a poorly understood biochemical system.
- Express and purify proteins, reconstitute complexes, and perform cell-based assays to determine the roles of individual proteins.
- Characterize how variants affect protein function to guide engineering efforts.
- Analyze and present findings to help shape hypotheses and design follow-up experiments.
- Maintain detailed experimental records and organized protein, plasmid, and cell inventories.
Requirements
- A bachelor’s or master’s degree, with a background in biochemistry, structural biology, or a related field.
- Experience using biochemical or biophysical methods to characterize protein structure, dynamics, or protein-protein interactions.
- Hands-on experience with mammalian cell culture, transfection, and cell-based assays.
- Curiosity, attention to detail, and a systematic approach to troubleshooting.
- Strong documentation, communication, and collaboration skills.
- Experience expressing and purifying challenging proteins or protein complexes.
- Experience designing and implementing large-scale screens or high-throughput experiments.
- Experience with molecular biology techniques such as cloning, mutagenesis, and plasmid preparation.
Skills
- Biochemistry
- Protein engineering
- Cell biology
- Protein interactions
- Protein activity
- Protein structure
- Experimental design
- Experimental interpretation
- Assay design
- Protein purification
- Mammalian cell culture
- Transfection
- Cell-based assays
- Troubleshooting
- Documentation
- Communication
- Collaboration
- Molecular biology
- Cloning
- Mutagenesis
- Plasmid preparation
Education Level
- Bachelor's degree
- Master's degree
About the Company
- Merge Labs is a frontier research lab with the mission of bridging biological and artificial intelligence to maximize human ability, agency and experience.
- We’re pursuing this goal by developing fundamentally new approaches to brain-computer interfaces that interact with the brain at high bandwidth, integrate with advanced AI, and are ultimately safe and accessible for anyone to use.
- On the Expression team, our work combines biochemistry, protein engineering, and cell biology to ensure the efficient assembly of complex protein systems for use as molecular readouts of neural activity.
Equal Opportunity
- Merge Labs does not discriminate on the basis of race, color, religion, national origin, age, sex, sexual orientation, gender, gender identity, gender expression, marital status, physical or mental disability, medical condition, genetic information, family status, ancestry, citizenship, U.S. military (state and federal) and veteran status, or any other legally protected status.
- It is our intention that all applicants be given equal opportunity and that selection decisions be based on job related factors.
- We are an equal opportunity employer.
- Pursuant to the San Francisco Fair Chance Ordinance, we will consider for employment qualified applicants with arrest and conviction records.
- We are committed to providing reasonable accommodations to applicants with disabilities, and requests can be made by emailing accommodations@merge.io.