Process Development Engineer I, Late-Stage Purification
Regeneron Pharmaceuticals · NY, US
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About the Role
Develop and transfer harvest, affinity chromatography, and viral inactivation processes for recombinant proteins using Quality by Design principles, collaborating with process development and manufacturing colleagues. This role contributes to a fast-growing, science-driven organization making a meaningful difference to patients worldwide.
Responsibilities
- Design and execute experiments at bench and pilot scale.
- Analyze data, draw conclusions, and propose next steps.
- Document results in laboratory notebooks and reports, and share findings with functional area and department leadership.
- Serve as purification development subject matter expert during manufacturing process transfer to support successful GMP batches.
- Collaborate cross-functionally with the process development team to enable a robust, cohesive manufacturing process.
- Support technology development, such as automating pilot-scale unit operations, improving bench-scale process models, building historical data workflows, and evaluating new raw materials, equipment, or techniques.
- Train and mentor peers, co-op students, and interns in running experiments, analyzing data, and documenting results.
- Contribute to lab equipment maintenance and lab safety to keep our working environment safe, effective, and efficient.
Requirements
- Bachelor's or Master's degree in Chemical Engineering, Biochemical Engineering, Biochemistry, or a related field.
- 0-2 years of recombinant protein purification experience.
- Hands-on experience with techniques such as depth filtration, disc stack centrifugation, column chromatography, virus retentive filtration, ultrafiltration/diafiltration, and buffer preparation.
- Solid understanding of, and practical experience in, purifying monoclonal antibodies or other biopharmaceuticals.
- Experience with process automation, such as hardware, control logic, and/or HMI development.
- Thrive in a team-based, collaborative environment; must be well-organized and can manage multiple projects efficiently.
Skills
- Protein purification techniques
- Akta chromatography systems
- HPLC
- UPLC
- Empower
- Unicorn
- JMP
- LIMS
- Python
- Ignition
- PI Historian
Location
- Tarrytown, NY
Work Type
- On-site
Experience Level
- 0-2 years
Education Level
- Bachelor's degree
- Master's degree
Salary/Compensations
- $80,300.00 - $131,100.00
Benefits
- Annual bonuses or other incentive plans
- Equity awards
- Pension or retirement benefits
- 401(k) company match
- Health and wellness programs
- Fitness centers
- Insurance benefits (e.g. medical, dental, vision, life and disability)
- Paid time off
- Family support benefits
About the Company
- Regeneron uses science and innovation to develop life-changing medicines for people with serious diseases.
- We are committed to building a workplace with an inclusive culture.
Equal Opportunity
- Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law.
- Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.