Principal Scientist (Director), Translational Medicine - Cardiovascular
Merck · Boston, MA, US
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About the Role
Translational Medicine is responsible for the early clinical development of novel therapeutics, collaborating closely with Discovery Sciences and late-stage Clinical Research. This role focuses on Cardiovascular Disease and related conditions, requiring a strong background in translational research and a collaborative spirit.
Responsibilities
- Lead the early clinical development strategy for novel therapy programs from Preclinical Candidate approval through Clinical Pharmacology testing (Phase 1) and clinical Proof-of-Concept (Phase 2).
- Develop biomarker strategies with cross-functional teams to guide studies from First-in-Human through clinical Proof-of-Concept, including Experimental Medicine studies.
- Contribute to novel target identification by partnering with discovery research teams to provide a clinical perspective and execute studies evaluating target relevance to human disease.
- Develop and execute clinical pharmacology strategies to support development from Proof-of-Concept (Phase 2) through worldwide marketing application.
- Serve as a key member of early development teams, providing leadership in designing and executing early clinical development strategy.
- Develop and execute early clinical strategy for novel therapeutics, including authoring clinical and biomarker plans for various development stages.
- Develop and execute studies to validate clinical platforms using established and novel biomarkers.
- Provide clinical expertise for novel target identification and validation, including designing preclinical and/or clinical pharmacology experiments.
- Ensure safe and timely execution of Phase I studies, collaborating with internal and external clinical study support staff and scientists.
- Provide clinical pharmacology support for programs through worldwide marketing application filing.
- Communicate and interpret study results clearly and timely to governance, experts, and committees.
- Contribute to the assessment of internal and external opportunities identified by Business Development and Licensing.
- Interface broadly with key functions across research sites worldwide.
Requirements
- Proven track record in clinical medicine or clinical research.
- Background in biomedical research.
- Demonstrated record of scientific scholarship and achievement including publications or presentations.
- Strong interpersonal, writing, and presentation skills.
- Ability to function in a team environment.
- Clinical Board Certification or Eligibility (Preferred).
- Subspecialty Clinical and Research experience in Cardiology or a related subspecialty (e.g., nephrology, pulmonary) is preferred but not required.
- Prior experience in translational research and/or early clinical development preferred but not required.
- Proven track record in clinical care of patient populations or management of clinical problem-solving.
Skills
- Cardiology
- Cardiovascular Medicine
- Clinical Trials
- Nephrology
- Scientific Research
- Translational Medicine
- Translational Research
Location
- USA - Massachusetts - Boston (MA Parcel B Laboratory)
Work Type
- Hybrid
- Regular
- Domestic Relocation
Experience Level
- Principal Scientist
- Clinical Director
Education Level
- MD
- MD/PhD
Salary/Compensations
- $260,300.00 - $409,700.00
Benefits
- Medical, dental, vision healthcare and other insurance benefits (for employee and family)
- Retirement benefits, including 401(k)
- Paid holidays, vacation, and compassionate and sick days
About the Company
- Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities.
- We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds.
- The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment.
- We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.
Equal Opportunity
- As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.
- As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.
- For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights, EEOC GINA Supplement.
- Learn more about your rights, including under California, Colorado and other US State Acts.