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About the Role
Amgen is seeking a Scientific Associate Director, Oncology Research to develop and lead a portfolio of antibody-based large-molecule therapeutics for solid tumors. This role involves implementing and advancing next-generation approaches for cancer therapeutics and working across Research and Development.
Responsibilities
- Define and lead preclinical research strategies for TCE and ADC therapies, including identification of novel target opportunities, prioritization of discovery investments, and advancement of programs toward development candidate nomination.
- Build and execute a cell-surface target discovery, prioritization, and validation strategy for pancreatic cancer, with the goal of establishing an innovative portfolio of first-in-class TCE and ADC therapies.
- Serve as Project Team Lead for Oncology portfolio programs, setting clear objectives and decision criteria, integrating cross-functional input, monitoring progress against milestones, and adapting strategy as new data emerges.
- Lead integrated cross-functional research plans across tumor biology, target validation, translational research, protein engineering, pharmacology, safety, clinical development, and commercial strategy.
- Apply translational biology to define patient populations, biomarkers, mechanisms of response and resistance, and development strategies, while anticipating and resolving complex scientific and programmatic challenges.
- Lead and develop a team of lab-based scientists, creating an inclusive, high-performing environment that promotes rigorous science, efficient execution, informed risk-taking, and professional growth.
- Shape Oncology Research strategy by identifying emerging scientific and industry trends, proposing new investment opportunities, and integrating enabling technologies—including computational biology and AI/ML—into target discovery, biological validation, and portfolio decisions.
- Establish productive external scientific collaborations and evaluate external innovation through scientific diligence in support of business-development and partnering opportunities.
- Communicate scientific strategy, evidence, risks, and recommendations clearly to project teams, governance bodies, senior management, collaborators, and external scientific audiences; lead development of governance materials, technical reports, publications, presentations, and patent applications.
Requirements
- Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] and 4 years of [Job Code’s Discipline and/or Sub-Discipline] experience OR Master’s degree and 7 years of [Job Code’s Discipline and/or Sub-Discipline] experience OR Bachelor’s degree and 9 years of [Job Code’s Discipline and/or Sub-Discipline] experience.
- PhD or equivalent doctoral training in cancer biology, immunology, molecular biology, pharmacology, genetics, translational medicine, or related discipline.
- Demonstrated experience leading at least one oncology TCE and/or ADC program from target discovery through development candidate nomination or an equivalent major discovery milestone.
- Deep knowledge of solid-tumor biology, with experience in pancreatic cancer or other treatment-resistant solid tumors strongly preferred.
- Broad expertise in human cancer genetics, oncogenic signaling, tumor dependencies, tumor–immune biology, mechanisms of response and resistance, and translational pharmacology, with experience building rigorous target-validation packages using genetic, cellular, biochemical, in vivo, and human evidence.
- Strong understanding of antibody-based therapeutic discovery, particularly TCEs and/or ADCs, with working knowledge of protein engineering, pharmacology, safety assessment, biomarker development, and clinical-development considerations.
- Demonstrated ability to independently define decision-enabling experiments, establish clear success and stop criteria, interpret complex datasets, and translate evidence into balanced program and portfolio recommendations.
- Proven success leading cross-functional teams in a matrixed drug-discovery environment and managing, mentoring, and developing scientists within inclusive, high-performing teams; able to lead through change while balancing scientific rigor, speed, and portfolio impact.
- Track record of external collaboration, scientific diligence, and influential scientific communication, supported by publications, patents, invited presentations, or recognition as a subject-matter expert.
Skills
- Antibody-based large-molecule therapeutics
- Oncology T-cell engager (TCE)
- Antibody-drug conjugate (ADC) programs
- Translational biology
- Cancer cell biology
- Human genetics
- Tumor cell signaling
- Mechanisms of response and resistance
- Translational pharmacology
- Project team leadership
- External collaboration
- Discovery strategy
- Computational biology
- AI/ML
Location
- US
Work Type
- Flexible work models where possible
Experience Level
- Associate Director
- 4 years of [Job Code’s Discipline and/or Sub-Discipline] experience
- 7 years of [Job Code’s Discipline and/or Sub-Discipline] experience
- 9 years of [Job Code’s Discipline and/or Sub-Discipline] experience
Education Level
- Doctorate degree PhD
- PharmD
- MD
- Master’s degree
- Bachelor’s degree
Salary/Compensations
- 190,951.65USD -258,346.35 USD
Benefits
- Comprehensive employee benefits package
- Retirement and Savings Plan with generous company contributions
- Group medical, dental and vision coverage
- Life and disability insurance
- Flexible spending accounts
- Discretionary annual bonus program
- Sales-based incentive plan
- Stock-based long-term incentives
- Award-winning time-off plans
About the Company
- Amgen is advancing a broad and deep pipeline and portfolio of medicines to treat heart disease, obesity and obesity-related conditions, rare diseases, inflammatory conditions and cancer.
- Amgen fosters an inclusive environment of ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients.
- Together, we compete in the fight against serious disease.
Equal Opportunity
- Amgen is an Equal Opportunity employer. We make all employment decisions without regard to race, color, religion, sex or any other characteristic protected by applicable law.
- We provide reasonable accommodations to applicants and employees with disabilities, consistent with legal requirements.
- Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.