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About the Role
Engitix Therapeutics is seeking a Senior Scientist with expertise in extracellular matrix (ECM) biology and 3D models to lead research in disease-associated ECM remodelling, develop translational disease models, and identify/validate therapeutic targets in fibrosis and oncology.
Responsibilities
- Drive experimental studies investigating ECM remodelling mechanisms in fibrosis and cancer.
- Develop, optimise and implement translational tissue-derived models of fibrosis and cancer.
- Develop and optimise ECM-derived and ECM-based 3D disease models.
- Establish robust and reproducible functional readouts capturing disease-relevant ECM remodelling, stromal-cell phenotypes and therapeutic responses.
- Support proteomic and peptidomic approaches to characterise ECM remodelling and enable target discovery and validation.
- Collaborate with computational and data-science teams to integrate experimental findings with large-scale omics and screening datasets.
- Analyse and critically interpret experimental data, maintain high-quality records, and communicate findings through reports and presentations.
Requirements
- Deep expertise in extracellular matrix biology, with a strong mechanistic understanding of ECM remodelling mechanisms in disease.
- Demonstrated hands-on experience developing and applying complex tissue-derived and/or 3D experimental models.
- Experience developing robust functional and phenotypic readouts for target validation, mechanistic studies and/or therapeutic testing.
- Experience working with primary stromal-cell populations, including fibroblasts and cancer-associated fibroblasts (CAFs), in disease-relevant contexts.
- Expertise in relevant imaging and tissue-analysis techniques, including immunofluorescence and quantitative analysis of tissue sections.
- Hands-on experience with relevant biochemical and molecular biology techniques.
- Hands-on experience in or familiarity with proteomics and/or peptidomics.
- Familiarity with analysis or interpretation of large-scale omics or functional screening datasets.
- Ability to plan, execute and critically assess experiments independently.
- Strong scientific judgement, including the ability to identify appropriate controls, recognise experimental limitations and troubleshoot technically challenging assays and models.
Skills
- Extracellular matrix (ECM) biology
- 3D models
- Fibrosis
- Oncology
- ECM remodelling
- Translational tissue-derived models
- Precision-cut tissue slices
- Ex vivo primary human tissue systems
- Decellularised matrices
- Complex 3D cellular models
- Target validation
- Mechanistic studies
- Therapeutic testing
- Cellular approaches
- Biochemical approaches
- Molecular biology approaches
- Imaging approaches
- Proteomic approaches
- Peptidomic approaches
- Functional readouts
- Stromal-cell phenotypes
- Therapeutic responses
- Target discovery
- Computational and data-science collaboration
- Large-scale omics datasets
- Functional screening datasets
- Immunofluorescence
- Quantitative analysis of tissue sections
- MSD or related immunoassays
- RNA/DNA extraction
- qRT-PCR
- Western blotting
- Gene knockdown approaches
- Fibrosis drug discovery
- Oncology drug discovery
- Translational drug discovery
Location
- White City Place, West London
Work Type
- Full-time
Experience Level
- Senior Scientist
- 3 years’ experience in academia or industry
Education Level
- PhD in Biomedical sciences, Tissue Engineering, Biochemistry, Biotechnology or related discipline
Benefits
- Private medical insurance
- Pension
- Bonus
- Employee perks
About the Company
- Engitix is a growing biotech company based in White City Place, West London.
- We are dedicated to developing better therapies for advanced fibrosis and solid tumours by leveraging our pioneering extracellular matrix (ECM) platform.
- Our platform allows the synthesis of realistic in vitro 3D models that serve as tools to transform our ability to identify new targets and biomarkers, determine mechanisms of action and more accurately predict the efficacy of therapeutic candidates.
- Join us today in our mission to create a healthier future for patients with life-threatening diseases such as fibrosis and cancer.