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About the Role
We are seeking an accomplished Senior Scientist to lead the design and execution of innovative experiments that accelerate drug discovery and development efforts, applying functional genomics and synthetic biology approaches, developing high-throughput screens, and driving new technology initiatives. The successful candidate will bring deep technical expertise and strong laboratory skills, communicate effectively, and work productively in a collaborative, cross-functional environment. You will also mentor junior scientists and stay current with the relevant literature and emerging technologies in the field. This is a contract position with an anticipated duration of approximately 9 months.
Responsibilities
- Lead the design, implementation, and optimization of biochemical, molecular, and cell-based assays to support high-throughput screening platform development.
- Scale high-throughput screening strategies for binder discovery in mammalian systems.
- Evaluate and pilot emerging technologies and experimental workflows to strengthen discovery capabilities, and make recommendations on their adoption.
- Develop and optimize automated workflows, ensuring data quality, reproducibility, and process efficiency.
- Partner with drug discovery, computational biology, and AI-based protein design teams to analyze, interpret, and share insights from screening data.
- Independently manage multiple projects, ensuring timely delivery of high-quality data and alignment with team goals.
- Maintain accurate records of experiments, protocols, and findings, and contribute to internal and external scientific presentations.
Requirements
- Ph.D. in Immunology, Molecular Biology, Cell Biology, Biochemistry, Functional Genomics, or a related field, with 4+ years of postdoctoral or industry experience.
- Proficiency with molecular biology techniques, complex library construction, flow cytometry, and cell line engineering.
- Experience with pooled screening and NGS-based readouts, including library preparation and sequencing QC.
- Demonstrated ability to troubleshoot complex experimental issues independently and to guide others through them.
- Strong data analysis capabilities, including proficiency with visualization and statistical software (e.g., GraphPad Prism, R, Python).
- Excellent written and verbal communication skills, with the ability to present scientific findings clearly and concisely to diverse audiences.
- Collaborative team player who can work effectively across interdisciplinary teams and drive cross-functional projects.
- Track record of scientific contributions, such as publications, patents, or internal technology development.
Skills
- Functional genomics
- Synthetic biology
- High-throughput screens
- Molecular biology techniques
- Complex library construction
- Flow cytometry
- Cell line engineering
- Pooled screening
- NGS-based readouts
- Library preparation
- Sequencing QC
- Data analysis
- GraphPad Prism
- R
- Python
- Scientific communication
Location
- San Francisco Bay Area
- Seattle
- London
Work Type
- Contract
- Onsite
Experience Level
- Senior Scientist
- 4+ years of postdoctoral or industry experience
Education Level
- Ph.D. in Immunology, Molecular Biology, Cell Biology, Biochemistry, Functional Genomics, or a related field
Salary/Compensations
- $65-$80 hourly
About the Company
- Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development.
- The company is leading the development of generative AI models to design protein and antibody therapeutics, enabling the creation of medicines against historically hard-to-drug molecular targets.
- It is also developing foundation models for biology and disease to enable better target elucidation and patient stratification.
- Collectively, these technologies aim to continually enable the identification of novel therapies and to improve success in drug development.
- Xaira is headquartered in the San Francisco Bay Area, Seattle, and London.
Equal Opportunity
- Xaira Therapeutics an equal-opportunity employer.
- We believe that our strength is in our differences.
- Our goal to build a diverse and inclusive team began on day one, and it will never end.