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About the Role
The HTS team builds the shared infrastructure that multiplies the scale and precision of every Merge experiment. We are building this capability from the ground up: selecting instruments, translating manual assays into standardized automated workflows, and transferring those workflows to the teams that run them every day. It's an early, hands-on team, and the work spans bench science, instrument integration, and process design.
Responsibilities
- Develop and optimize plate-based assays across molecular biology and cell biology, with a focus on reproducibility and scalability.
- Translate validated assays into automated workflows, and partner with program teams to establish SOPs, train users, and transfer methods for routine execution.
- Identify sources of experimental variability and work with scientists to improve assay performance and robustness.
- Prepare samples, reagents, and cell cultures, and execute experiments with accuracy and consistency.
- Operate, maintain, and troubleshoot laboratory instruments.
- Collect, organize, and perform initial quality control on experimental data, and maintain detailed records, sample metadata, and inventory in digital laboratory systems.
- Help maintain a safe, organized, and efficient laboratory environment.
Requirements
- BS, BA, or MS in Biology, Biochemistry, Neuroscience, Bioengineering, or a related field.
- Strong hands-on experience in assay development and high-throughput screening, including designing, optimizing, and validating plate-based assays and executing them at scale.
- Depth in one or more of the following areas: AAV production and analytics (mammalian cell transfection, viral purification, and qPCR-based titering), Cell biology (cell culture, transfection or transduction, and plate-based assessment of cell viability or function), Molecular biology (PCR/qPCR assay development, nucleic-acid preparation and quantification, or sequencing library preparation).
- Experience with laboratory automation and a systematic approach to troubleshooting and improving experimental workflows.
- Strong written documentation and communication skills, and a collaborative mindset for working across scientific and engineering disciplines.
Skills
- Assay development
- High-throughput screening
- Plate-based assays
- AAV production and analytics
- Mammalian cell transfection
- Viral purification
- qPCR
- Cell biology
- Cell culture
- Transfection
- Transduction
- Cell viability assessment
- Cell function assessment
- Molecular biology
- PCR
- Nucleic-acid preparation
- Nucleic-acid quantification
- Sequencing library preparation
- Laboratory automation
- Troubleshooting
- Experimental workflow improvement
- Written documentation
- Communication
- Collaboration
- Primary neuron culturing
- iPSC-derived neuron culturing
- Neuronal viability assessment
- Neuronal function assessment
- Hamilton liquid handlers
- Tecan liquid handlers
- Opentrons liquid handlers
- Python
- R
- Scripting
- Data analysis
- LIMS
- ELNs
- Sample-tracking systems
- Automated data pipelines
Education Level
- BS
- BA
- MS
About the Company
- Merge Labs is a frontier research lab with the mission of bridging biological and artificial intelligence to maximize human ability, agency and experience.
- We’re pursuing this goal by developing fundamentally new approaches to brain-computer interfaces that interact with the brain at high bandwidth, integrate with advanced AI, and are ultimately safe and accessible for anyone to use.
Equal Opportunity
- Merge Labs does not discriminate on the basis of race, color, religion, national origin, age, sex, sexual orientation, gender, gender identity, gender expression, marital status, physical or mental disability, medical condition, genetic information, family status, ancestry, citizenship, U.S. military (state and federal) and veteran status, or any other legally protected status.
- It is our intention that all applicants be given equal opportunity and that selection decisions are based on job related factors.
- We are an equal opportunity employer.
- Pursuant to the San Francisco Fair Chance Ordinance, we will consider for employment qualified applicants with arrest and conviction records.
- We are committed to providing reasonable accommodations to applicants with disabilities, and requests can be made by emailing accommodations@merge.io.