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About the Role

Amgen is seeking a Senior Scientific leader in skin biology to shape therapeutic hypotheses, programs, and capabilities across Inflammation Research. This role connects experimental biology with human data, computation, AI, automation, and emerging technologies to accelerate decisions from target discovery through early development.

Responsibilities

Provide scientific leadership for discovery programs, technology platforms, or strategic initiatives focused on skin biology and inflammatory disease.
Define compelling, human-biology-driven hypotheses and translate them into integrated experimental and computational strategies for target identification, validation, patient segmentation, and differentiated therapeutic approaches.
Design, direct, and interpret complex studies using relevant human tissues and advanced preclinical systems.
Continuously apply AI-enabled, computational, agentic, and data-science approaches to synthesize evidence, generate mechanistic insights, prioritize experiments, and improve the speed and quality of scientific decision-making.
Partner with computational scientists, engineers, automation experts, translational scientists, human geneticists, clinicians, and project teams to develop integrated datasets and predictive biological models.
Identify, evaluate, and implement emerging technologies that materially improve how skin biology is studied.
Guide program strategy, milestone definition, experimental prioritization, risk assessment, and resolution of complex scientific issues.
Be accountable for scientific quality and delivery against longer-term objectives.
Influence project, departmental, and broader functional strategy by recognizing external scientific and technology trends and translating them into actionable opportunities.
Lead and contribute to cross-functional teams, creating clarity in an evolving environment and connecting expertise across the organization to deliver results.
Coach and provide scientific and technical guidance to colleagues across the function, while fostering an inclusive, connected, curious, and high-performing research culture.
Communicate scientific strategy, evidence, uncertainty, and recommendations effectively to project teams, senior leaders, governance bodies, and external scientific audiences.
Build external scientific eminence through influential collaborations, conference participation, publications, patents, and other reviewed scientific or technical outputs.

Requirements

Doctorate degree PhD, PharmD, or MD and 3 years of relevant experience
Master’s degree and 6 years of relevant experience
Bachelor’s degree and 8 years of relevant experience
Deep expertise in keratinocyte biology, stromal or fibroblast biology, skin inflammation, epithelial-immune crosstalk, wound repair, tissue remodeling, and/or inflammatory diseases of the skin.
Strong record of applying human tissues, disease-relevant cellular systems, organotypic models, spatial biology, single-cell methods, imaging, omics, functional genomics, or perturbational approaches to define mechanisms.
Demonstrated experience using AI-enabled tools, machine learning, computational biology, agentic research workflows, advanced analytics, or data integration to generate and test biological hypotheses.
Ability to identify where technology can create a step change in biological understanding, then build partnerships and workflows that convert promising concepts into robust capabilities.
Experience advancing drug discovery programs and understanding how target biology connects to modality, biomarkers, translational strategy, clinical differentiation, and portfolio value.
Evidence of scientific influence beyond an immediate team, such as cross-functional leadership, external collaborations, invited presentations, senior authorship, patents, or other recognized contributions.
Excellent written and verbal communication skills, including the ability to frame complex science, uncertainty, and recommendations for technical and senior leadership audiences.
Demonstrated excellence in project leadership and the ability to balance scientific rigor, strategic focus, urgency, adaptability, and operational execution.
Commitment to coaching others, sharing knowledge, and building a connected, inclusive, and inspiring environment in which colleagues can thrive.

Skills

Skin Biology
Inflammation Research
Therapeutic Hypotheses
Program Development
Capability Building
Experimental Biology
Human Data Analysis
Computation
Artificial Intelligence (AI)
Automation
Emerging Technologies
Target Discovery
Early Development
Keratinocyte Biology
Stem Cells
Stromal Biology
Fibroblast Biology
Epithelial-Neuro-Immune Interactions
Skin Inflammation
Tissue Remodeling
Barrier Biology
Diseases of the Skin
Preclinical Systems
Primary Cells
Organotypic Cultures
Co-culture Systems
Spatial Biology
Single-cell Approaches
Perturbational Biology
In Vivo Models
AI-enabled Tools
Computational Biology
Agentic Workflows
Data Science
Data Integration
Predictive Biological Models
Next-generation Tissue Models
Imaging
Multi-omics
High-content Phenotyping
Functional Genomics
Scalable Experimental Platforms
Risk Assessment
Scientific Strategy
Cross-functional Leadership
Communication Skills
Project Leadership
Scientific Rigor
Strategic Focus
Adaptability
Operational Execution
Coaching
Knowledge Sharing
Inclusive Environment Building

Location

Work Type

Flexible work models where possible

Experience Level

Senior Principal Scientist
3 years of relevant experience (with Doctorate)
6 years of relevant experience (with Master's)
8 years of relevant experience (with Bachelor's)

Education Level

Doctorate degree (PhD, PharmD, or MD)
Master’s degree
Bachelor’s degree

Salary/Compensations

170,568.65 USD - 230,769.35 USD

Benefits

Comprehensive employee benefits package
Retirement and Savings Plan with generous company contributions
Group medical, dental and vision coverage
Life and disability insurance
Flexible spending accounts
Discretionary annual bonus program
Stock-based long-term incentives
Award-winning time-off plans

About the Company

Amgen's mission is to serve patients living with serious illnesses.
Amgen pioneered the biotech industry in its fight against tough diseases.
Amgen is advancing a pipeline and portfolio of medicines for heart disease, obesity, rare diseases, inflammatory conditions, and cancer.
Amgen's culture is collaborative, innovative, and science-based.

Equal Opportunity

Amgen is an Equal Opportunity employer.
We make all employment decisions without regard to race, color, religion, sex or any other characteristic protected by applicable law.
We provide reasonable accommodations to applicants and employees with disabilities, consistent with legal requirements.
Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.