Impress employers and recruiters.
Choose from hundreds of resume examples.
Impress employers and recruiters.
Choose from hundreds of resume examples.
Tailor your resume to this Associate Scientist, Cell Line Development role.
Rezi rewrites your resume against Denali Therapeutics's job description. Free.
Tailor your resume to this Associate Scientist, Cell Line Development role.
Rezi rewrites your resume against Denali Therapeutics's job description. Free.
Don't guess if your resume is good enough.
See how it scores against the Associate Scientist, Cell Line Development posting at Denali Therapeutics — free, in seconds.
Don't guess if your resume is good enough.
See how it scores against the Associate Scientist, Cell Line Development posting at Denali Therapeutics — free, in seconds.
About the Role
Denali Therapeutics is seeking a scientist to join the Bioprocess Development team, focusing on cell line development for novel therapeutic molecules. The role involves generating commercially viable cell lines for bispecific antibodies, Fc fusion proteins, and enzyme fusions.
Responsibilities
- Support the development of Denali’s mammalian biotherapeutic production platform to generate commercially viable cell lines.
- Execute cell line development activities including transfection, selection, single cell sorting, clone imaging, clone selection, and clone banking for pipeline projects.
- Design, execute, and interpret cell line development experiments in collaboration with other scientists, utilizing JMP statistical software for DOE experiments and figure generation.
- Write technical and summary reports, including cell line development reports for regulatory filings.
- Effectively communicate findings with cross-functional teams and participate in scientific discussions.
- Maintain accurate and detailed laboratory notebooks and relevant documentation.
- Cross-functionally support cell culture process development through bioreactor production runs and DOE-based screening experiments.
- Evaluate, optimize, and implement characterization assays such as qPCR, Western blots, and flow cytometry.
Requirements
- BA/BS or MS degree in Molecular Biology/Biochemistry/Cell Biology or related field.
- Technical proficiency in mammalian cell culture and upstream process development, preferably in an industrial laboratory.
- 2+ years of experience working in a laboratory environment.
- Experience in CHO cell line development for biologics in a CMC setting is preferred.
- Proficiency with protein characterization techniques such as Octet, SDS-PAGE, Caliper, and HPLC.
- Demonstrated ability to organize, analyze, and interpret experimental data, specifically in JMP and Excel.
- Ability to work effectively and collaboratively with other scientists in cross-functional project teams.
- Excellent oral presentation and written communication skills.
Skills
- JMP statistical software
- DOE experiments
- qPCR
- Western blots
- Flow cytometry
- Octet
- SDS-PAGE
- Caliper
- HPLC
- Mammalian cell culture
- Upstream process development
- CHO cell line development
- CMC setting
- Protein characterization
- Data analysis
- Data interpretation
- Excel
Location
- Onsite
Work Type
- Full-time
Experience Level
- 2+ years of experience
Education Level
- BA/BS or MS degree
Salary/Compensations
- $106,000.00 to $138,000.00
Benefits
- 401k
- Healthcare coverage
- ESPP
About the Company
- Denali Therapeutics Inc. is a biotechnology company pioneering a new class of biotherapeutics designed to cross the blood-brain barrier (BBB) using its proprietary TransportVehicle™ platform.
- The company has the first FDA-approved biologic specifically designed to cross the BBB, a clinically validated delivery platform, and a growing portfolio of therapeutic candidates.
- Denali is advancing toward its goal of delivering effective medicines to transform the lives of people living with neurodegenerative diseases, lysosomal storage disorders, and other serious diseases.
Equal Opportunity
- Denali is committed to its core company value of unity by creating a diverse and inclusive environment.
- We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.