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About the Role

Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease. The future is coming, enabled and enriched by machine learning, where diseases are curtailed or cured starting with better and faster drug discovery. Join an interdisciplinary team driving groundbreaking innovation and play a meaningful role in achieving ambitious goals within an inspiring and collaborative culture.

Responsibilities

Tailor and implement project-specific safety assessment strategies with an AI-first approach to support small molecules and biologics.
Design screening cascades and mechanistic experiments to elucidate and mitigate safety risks, supporting project progression in a data-driven manner.
Provide technical expertise to develop SAR understanding of toxicology liabilities to enable optimisation of chemical and biological matter.
Define regulatory safety assessment packages to support successful acceptance by regulatory agencies.
Communicate clear integrated risk assessments and recommendations to internal stakeholders.
Author and defend toxicology sections of regulatory documents.
Maintain and develop close relationships with the CRO network to ensure high quality and timely data generation.
Leverage the scientific expertise of external collaborators to enhance the team's impact.
Oversee the delivery of data generation campaigns purposefully designed to support the development of AI-based toxicology models.
Empower fellow team members by sharing expertise in toxicology, fostering a culture of continuous learning and mutual support.
Embrace and champion a culture of inclusion and continuous professional development.

Requirements

PhD in Toxicology, Pharmacology, Biology, with 8+ years of professional experience working in a senior toxicology role within a biotech or pharma setting.
Proven track record of delivering successful non-clinical safety strategies as a project representative across different therapy areas.
Demonstrated experience designing, implementing and filing successful IND packages for both small molecules and biologics.
Deep understanding of Global Regulatory Guidelines regarding safety assessment.
Experience of partnering closely with Discovery and Clinical teams.
Excellent communication (written and verbal), interpersonal and influencing skills, with an ability to work effectively in a cross-functional, collaborative team environment.
Track record of creative problem solving with a strong growth mindset, adaptability, willingness to challenge conventional thinking and eagerness to learn new concepts.

Skills

Toxicology
Pharmacology
Biology
AI-first approach
Drug discovery
Safety assessment
Small molecules
Biologics
Screening cascades
Mechanistic experiments
SAR understanding
Regulatory guidelines
IND packages
CRO management
AI/ML techniques

Location

Remote

Work Type

Hybrid

Experience Level

8+ years of professional experience
Senior toxicology role

Education Level

About the Company

Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system.
Our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed.
Our name comes from the belief that there is an underlying symmetry between biology and information science.
By harnessing AI’s powerful capabilities, we can use it to model complex biological phenomena to help design novel molecules, anticipate how drugs will perform and develop innovative medicines to treat and cure some of the world’s most devastating diseases.
We have built a world-leading drug design engine comprising AI models that are capable of working across multiple therapeutic areas and drug modalities.
We are continually innovating on model architecture and developing cutting-edge capabilities to advance rational drug design.
Every day, and with each new breakthrough, we’re getting closer to the promise of digital biology, and achieving our ambitious mission to one day solve all disease with the help of AI.
The Toxicology team operates at the cutting-edge intersection of preclinical development and artificial intelligence, redefining how safety is assessed from the very beginning of the drug discovery process.
Through collaboration with drug program teams, subject matter experts and ML researchers, we ensure that safety is a key pillar of our drug design engine.
We shape the development of state-of-the-art toxicology predictive models, optimising their context of use to rethink drug discovery from HitID to First in Human trials.
We are guided by our shared values: Thoughtful, Brave, Determined, Together.
We believe that to be successful we need a team with a range of skills and talents.
We're building an environment where collaboration is fundamental, learning is shared and every employee feels supported and able to thrive.
We value unique experiences, knowledge, backgrounds, and perspectives, and harness these qualities to create extraordinary impact.

Equal Opportunity

We are committed to equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, disability, age, citizenship, marital, domestic or civil partnership status, sexual orientation, gender identity, pregnancy or related condition (including breastfeeding) or any other basis protected by applicable law.
If you have a disability or additional need that requires accommodation, please do not hesitate to let us know.