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About the Role
Lead the biology of small molecule programs as they move rapidly from hit to lead, through lead optimization and towards candidate nomination. Act as biology lead on a drug discovery project, working closely with medicinal chemists, computational scientists and AI specialists in a small, fast-moving team. Own the project’s biology day to day, from screening cascade design and CRO-run experiments to data interpretation and recommendations to leadership at key decision gates. Bring your own ideas on how to differentiate our projects from competitors working on the same targets.
Responsibilities
- Act as biology lead on a drug discovery project, driving its biological strategy and progression from hit-to-lead through lead optimization
- Design, implement, and maintain screening cascades to generate high-quality, decision-enabling in vitro and in vivo data
- Sign off biological experiments and collaborate with external CROs on study design, model selection, and data quality
- Analyse and interpret biological and pharmacological data, building clear data packages and recommendations for DDS leadership and co-founders at project decision gates
- Identify scientific risks early, clearly voice concerns, and highlight opportunities to accelerate project progression
- Bring independent ideas on project direction and differentiation from competitor programs
- Contribute to target identification and new project ideation across oncology and CNS
- Foster cross-functional collaboration, integrating biology with chemistry, modeling, and platform teams
Requirements
- PhD in biological sciences (e.g., pharmacology, molecular biology, chemical biology, biochemistry)
- Significant industry experience (typically ~5+ years) in small molecule drug discovery within biotech or pharma
- Hands-on experience progressing projects through hit-to-lead and/or lead optimization
- Strong expertise in in vitro pharmacology and screening cascade design
- Demonstrated expertise in oncology or CNS
- Solid understanding of experimental biology, with hands-on wet lab experience to effectively guide and challenge external partners
- Confident communicator, comfortable presenting data-driven recommendations in a small, fast-paced team
Skills
- Oncology
- CNS
- In vitro pharmacology
- Screening cascade design
- Experimental biology
- Wet lab experience
- Communication
- Data analysis
- Data interpretation
- Project management
- Collaboration
- AI
- Physics-based modeling
- Statistical mechanics
- Generative AI
- Medicinal chemistry
- Computational chemistry
- Biology
- Translational science
- Molecular simulations
Location
- Paris
- London
Work Type
- Flexible work arrangements
- Up to two remote days per week
Experience Level
- ~5+ years industry experience in small molecule drug discovery
Education Level
- PhD in biological sciences
About the Company
- AQEMIA is a drug invention company dedicated to creating entirely new medicines to address major unmet medical needs.
- Our proprietary molecule-invention platform, QEMI, combines cutting-edge science with advanced technology, powered by physics-based modeling, statistical mechanics, and generative AI.
- We focus on inventing never-before-seen molecules, without relying on experimental data, and advancing them into a growing pipeline of proprietary programs and strategic partnerships with leading pharmaceutical companies.
- Our most advanced preclinical programs are currently in vivo optimization, targeting diseases still waiting for effective treatments.
- AQEMIA brings together a diverse, multidisciplinary team of 80+ professionals based in Paris and London.
- Our scientists and engineers, including chemists, physicists, machine learning experts, and software engineers, work side by side to push the boundaries of early-stage drug discovery.
- The Drug Discovery Sciences team combines expertise in medicinal chemistry, computational chemistry, biology, and translational science.
- Working at the intersection of AI-driven drug design, molecular simulations, and experimental science, the team is responsible for driving scientific excellence across Aqemia’s drug discovery programs and delivering clinical candidates.
- We are proud to be part of the French Tech 40 and France 2030, highlighting our role as a key player in Europe’s DeepTech ecosystem.
- We have raised $100M from leading European and International investors.
Equal Opportunity
- We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses and identifying potential inconsistencies or verification signals in application materials based on available information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.