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About the Role

Cold Spring Harbor Laboratory is seeking an experienced and highly collaborative Ph.D. or M.D. scientist to lead the Histology Core Facility. This role provides strategic, operational, and scientific leadership for a busy, growing histology core supporting cutting-edge research. The Director will ensure outstanding day-to-day operations and develop a forward-looking vision for the core's growth, including expansion into digital pathology and spatial biology workflows.

Responsibilities

Oversee all day-to-day operations of the core facility, including personnel management, project coordination, quality control, budgeting input, equipment oversight, and customer interactions.
Optimize existing workflows for improved throughput and efficiency.
Identify, develop, and implement emerging technologies and analytical approaches to enhance institutional research capabilities.
Provide leadership, supervision, mentoring, and professional development for core facility staff.
Manage and improve operational workflows, turnaround times, communication, and project tracking systems.
Develop and execute a strategic vision for the growth and modernization of the Histology Core.
Expand institutional capabilities in digital pathology, whole-slide imaging, immunofluorescence (IF), and immunohistochemistry (IHC), and quantitative image analysis.
Build integrated workflows with the Single Cell Biology Core to support spatial transcriptomics and spatial biology applications.
Consult with investigators on experimental design, tissue processing strategies, histological methods, and image analysis approaches.
Oversee and participate in experimental workflows, including tissue processing, embedding, sectioning, staining, IF/IHC, and in situ hybridization.
Develop, validate, and implement new histology, imaging, and analytical workflows.
Advise on acquisition, optimization, maintenance, and utilization of instrumentation and core technologies.
Support digital pathology and image analysis workflows, including whole-slide imaging and quantitative image analysis.
Collaborate with institutional investigators and other core facilities on emerging technologies, including multiplex and cyclic immunofluorescence, spatial transcriptomics, and computational pathology approaches.
Support institutional grant applications and reporting requirements, including renewals of the Cancer Center Support Grant and progress reports.
Participate in all Cancer Center activities, including advisory boards and grant reviews, as requested by the Cancer Center leadership.

Requirements

At least 3 years of experience working in a histology, pathology, or related academic core facility.
Demonstrated experience helping develop or expand core facility technologies, workflows, or scientific capabilities.
Experience managing or supervising technical staff within a shared-resource or service-oriented environment.
Expertise in digital pathology, whole-slide imaging, and/or quantitative image analysis.
Experience with image analysis platforms such as Visiopharm, HALO, QuPath, or related software.
Experience with advanced multiplex imaging approaches, including cyclic immunofluorescence and spatial biology workflows.
Computational and analytical experience related to image analysis, including cell phenotyping, spatial/neighborhood analysis, and high-dimensional imaging datasets.
Experience integrating histology and imaging workflows with spatial transcriptomics or single-cell technologies.
Experience evaluating, implementing, and optimizing new instrumentation and technologies.

Skills

Digital pathology
Whole-slide imaging
Quantitative image analysis
Image analysis platforms (Visiopharm, HALO, QuPath, or related software)
Advanced multiplex imaging approaches
Cyclic immunofluorescence
Spatial biology workflows
Computational and analytical experience related to image analysis
Cell phenotyping
Spatial/neighborhood analysis
High-dimensional imaging datasets
Integrating histology and imaging workflows with spatial transcriptomics or single-cell technologies
Evaluating, implementing, and optimizing new instrumentation and technologies

Location

New York

Work Type

Regular

Experience Level

3+ years of experience working in a histology, pathology, or related academic core facility
Experience managing or supervising technical staff

Education Level

Ph.D. or M.D. preferred
Master's or bachelor's degree with extensive histology experience will also be considered

Salary/Compensations

$100,000-125,000 per annum

Benefits

Exceptional health benefits
Retirement plans
Time off
Range of recognition and wellness programs

About the Company

Cold Spring Harbor Laboratory is a world-renowned biomedical research institution.
It has shaped contemporary biomedical research and is the home of eight Nobel Prize laureates.
CSHL provides a highly dynamic and interactive research environment.
Offers timely exposure to advances in various biomedical research fields and interaction with a broad range of researchers from all over the world through its renowned Meetings and Courses program.
Believes that science is for everyone and researchers have a wide variety of backgrounds.

Equal Opportunity

CSHL is an EO Employer.
All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability or protected veteran status.
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