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About the Role

The Research Associate I/II will support Lexeo’s human induced pluripotent stem cell–derived cardiomyocyte (iPSC-CM) platform, a core in vitro system used to evaluate target engagement, mechanism of action, and potency across discovery and preclinical programs. This hands-on laboratory role will execute established cellular and molecular assays, contribute to assay development, and generate high-quality data. This is an exciting opportunity to join a cutting-edge drug discovery team advancing new therapies for patients with genetic heart disease.

Responsibilities

Generate and validate cellular knockdown and overexpression models
Culture and maintain human iPSC-derived cardiomyocytes and other mammalian cell lines using aseptic technique
Perform ddPCR, qPCR, conventional PCR, gel electrophoresis, Western blotting, and ELISA to support mechanism-of-action and target-validation studies
Maintain complete and accurate laboratory records and contribute to the development and revision of assay SOPs
Analyze experimental data and prepare concise summaries for Preclinical team

Requirements

Bachelor’s degree in cell biology, molecular biology, pharmacology, or a related field
1-3 years of industry and/or academic lab experience
Hands-on experience culturing iPSC and differentiation protocols for cardiomyocytes/neurons
Hands-on experience with cellular transfection methods
Experience with several of the following methods: ddPCR, qPCR, semi-quantitative PCR, Western blotting, ELISA, flow cytometry, and fluorescence microscopy
Strong laboratory skills, rigorous record-keeping, attention to detail
Ability to work effectively in a fast-paced environment
Ability to work onsite 5 days/week

Skills

ddPCR
qPCR
conventional PCR
gel electrophoresis
Western blotting
ELISA
flow cytometry
fluorescence microscopy
iPSC culture
cardiomyocyte differentiation
neuron differentiation
cellular transfection
high-throughput screening platforms
automation
workflows
Jess automated Western blotting platform
TR-FRET
NanoBiT
FLIPR
MEA assays
engineered heart tissue models
cardiac biology
AI-native, agentic lab-in-the-loop workflows
experimental design
automated execution
real-time data analysis
iterative decision-making

Location

New York City HQ

Work Type

Onsite

Experience Level

1-3 years industry and/or academic lab experience

Education Level

Bachelor’s degree in cell biology, molecular biology, pharmacology, or a related field

About the Company

Lexeo Therapeutics is a New York City-based, clinical stage company dedicated to reshaping the path of genetic disease.
By advancing pioneering science, Lexeo seeks to set a new standard in the treatment of cardiovascular and neurological genetic diseases, charting the path to patient outcomes once thought out of reach.
The Company is advancing a portfolio of therapeutic candidates designed to address the underlying genetic causes of disease, including LX2006 for Friedreich ataxia (FA), LX2020 for plakophilin-2 (PKP2) arrhythmogenic cardiomyopathy, and others in devastating diseases with high unmet need.

Equal Opportunity

LEXEO Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.