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About the Role

AAVantgarde is seeking a Senior Director, Clinical Strategy and Operational Excellence to enhance the effectiveness and efficiency of the CMO’s office. This broad role involves acting as a trusted advisor and strategic project manager, coordinating cross-functional initiatives, ensuring team alignment, managing finances and budget, and serving as a key liaison between the CMO, her team, and stakeholders. The position offers flexible scope with the potential to shape the role over time.

Responsibilities

Partner with the CMO team to define, prioritize, and drive key initiatives aligned with the company’s clinical and business objectives.
Provide insights, analysis, and recommendations to support decision-making and organizational alignment.
Manage the day-to-day operations of the CMO’s office, ensuring seamless execution of activities.
Drive project management efforts, tracking milestones, deliverables, and key performance indicators (KPIs) for clinical and medical affairs initiatives.
Facilitate cross-departmental collaboration to ensure alignment on timelines, goals, and resource allocation.
Represent the CMO in key internal meetings, synthesizing and relaying critical information.
Collaborate with the Finance team to oversee budgets for clinical operations, medical affairs, and associated clinical development functions.
Monitor budget performance, identify variances, and develop action plans to ensure financial alignment with organizational goals.
Support the CMO in evaluating resource needs and making data-driven recommendations for budget allocation.
Develop and track financial forecasts, ensuring alignment with cross-functional project plans and priorities.
Partner with department heads to optimize spending efficiency while maintaining high standards of operational excellence.
Serve as the primary liaison between the CMO and internal teams, external partners, and stakeholders, ensuring clear and consistent communication.
Draft executive presentations, reports, and correspondence for internal and external audiences, Italian language translations (if needed), including the Board of Directors, regulatory agencies, and key partners.
Develop and execute communication strategies to articulate the CMO’s vision and priorities effectively.
Partner with CMO Leadership Team to ensure alignment across leadership initiatives.
Foster a culture of accountability, transparency, and innovation across the clinical development team.
Lead or support high-priority special projects and initiatives as assigned by the CMO.
Conduct research and analysis on emerging trends, competitor activity, and regulatory developments in the biotech and pharmaceutical landscape.

Requirements

Significant experience in biotechnology, pharmaceuticals or another complex, fast-paced environment, with experience in a clinical-stage or emerging biotech strongly preferred.
Experience managing a team and leading project delivery, creating project plans and understanding dependencies across the functions and projects.
Demonstrated experience leading complex, cross-functional programs with multiple concurrent workstreams, ideally supporting more than one clinical development program.
Strong track record of end-to-end project and program management, including development of integrated plans, identification of dependencies, milestone and deliverable tracking, risk management and proactive escalation.
Experience working directly with senior executives, with the judgement, discretion and confidence to manage priorities on their behalf and drive follow-through across senior stakeholders.
Demonstrated ability to manage an executive-level deliverables portfolio/calendar, spanning granular activities such as review and contribution to key documents through to strategic milestones, governance meetings and Board/investor deliverables.
Experience coordinating activities across Clinical Development, Clinical Operations, Biometrics, Medical Affairs, Regulatory and other relevant functions is highly desirable.
Experience with budget management, forecasting and resource planning, preferably within clinical development.
Demonstrated ability to produce high-quality executive materials and synthesize complex information into clear recommendations, decisions and actions.
Track record of operating effectively in a lean, rapidly evolving organization, taking ownership and delivering with pace, accuracy and limited supervision.

Skills

Exceptional organizational, analytical, and leadership skills.
Ability to project manage across concurrent clinical development programs, integrating cross-functional workstreams, dependencies, milestones and competing priorities.
Ability to move seamlessly between strategic and detailed execution.
Ability to translate CMO priorities into clear actions, secure inputs, follow up proactively, and escalate risks early.
High degree of autonomy, urgency, and discretion.
Comfort working with incomplete information and adapting rapidly as priorities evolve.
Solution-oriented mindset with a structured yet creative approach to problem solving.
Ability to manage multiple priorities simultaneously and deliver critical assignments on time and within budget.
Excellent written and oral communication skills.
Ability to develop well-structured and high-impact materials.
Ability to present to diverse audiences and lead meetings with senior stakeholder groups.
Strong interpersonal skills and proven ability to develop effective working relationships across all levels of the organization.
Energy, pace, and a strong bias for action while maintaining high standards of quality and follow-through.

Experience Level

Senior

Education Level

Bachelor's degree minimum
Advanced degree in life sciences, business, project/program management or a related discipline is advantageous.

About the Company

AAVantgarde is a fast-growing clinical-stage biotech company innovating cutting edge research and development to advance gene therapies for rare diseases.

Equal Opportunity

At AAVantgarde, we are committed to fostering a welcoming, collaborative, and inclusive environment.
We believe in providing equal opportunities for all and do not discriminate on the basis of race, colour, religion, sex, sexual orientation, gender identity, national origin, disability, or any other legally protected characteristics.
All applicants will receive equal consideration for employment.