Principal Scientist / Associate Director, Developability & Protein Sciences
Cartography Biosciences · CA, US
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About the Role
Lead developability and protein sciences for bispecific and multispecific antibody programs, including T-cell engagers. Own biophysical and developability screening, expression, and purification. Manage a team of scientists and contribute to cross-functional therapeutic program teams. This is a hands-on, hybrid role with approximately half of your time spent at the bench.
Responsibilities
- Deliver developability and biophysical data for therapeutic programs as candidates advance.
- Own the developability screening cascade, including thermal stability, aggregation, self-association, charge variants, hydrophobicity, polyspecificity, and molecular integrity.
- Integrate in silico biophysical property assessment with experimental data to prioritize and engineer candidates.
- Characterize advanced leads and development candidates through stress studies, PTM mapping, and early formulation development.
- Define and own developability criteria at each program decision gate.
- Expand protein analytics capabilities to support AI/ML-driven antibody engineering.
- Oversee research-stage protein production from 1 mL to 10 L scale, in house and through external partners.
- Optimize transient production of multi-chain bispecific and multispecific assemblies.
- Direct purification strategies to resolve bispecific product-related species.
- Scale plate-based expression and purification to support AI/ML-driven antibody engineering.
- Deliver low-endotoxin, high-monomer material meeting in vivo dosing specifications.
- Lead Protein Sciences work on cross-functional therapeutic program teams, integrating developability and manufacturability risks.
- Align Antibody Engineering, Pharmacology, and Computational Biology around program goals, timelines, and gate decisions.
- Communicate data, risks, and recommendations clearly to program teams and leadership.
- Manage, mentor, and develop scientists in protein purification and analytics.
- Set the day-to-day practices and priorities for the protein sciences function.
- Build data capture, analysis, and automation into team workflows.
Requirements
- PhD in protein science, biochemistry, biophysics, chemical or biological engineering, or a related discipline with 5+ years (Principal Scientist) or 8+ years (Associate Director) of biopharmaceutical industry experience; or an MS with commensurate additional directly relevant experience.
- Hands-on experience with bispecific or multispecific antibodies, including analysis of product-related species.
- Hands-on expertise with biophysical and developability methods, such as DSF or DSC, analytical SEC, IEX, HIC, CE-SDS, intact mass, self-association assays, and polyspecificity assays.
- Developability triage experience in a research or discovery setting, translating biophysical data into candidate selection decisions.
- Experience with mammalian transient expression and multi-step antibody purification on FPLC systems, including Protein A capture and polishing.
- Experience serving as the protein sciences or developability expert on cross-functional therapeutic project teams.
- Demonstrated ability to lead cross-functional teams without direct authority.
- Experience managing or mentoring scientists.
- Hands-on experience writing code to analyze data or automate lab workflows (e.g. Python or R).
Skills
- Bispecific or multispecific antibodies
- Developability screening
- Biophysical characterization
- Protein expression
- Protein purification
- FPLC systems
- Protein A capture
- Ion exchange chromatography
- Hydrophobic interaction chromatography
- Mixed-mode chromatography
- Mammalian transient expression
- Cross-functional team leadership
- Data analysis
- Workflow automation
- Python
- R
- In silico biophysical property assessment
- PTM characterization
- Formulation development
- AI/ML-driven antibody engineering
Location
- South San Francisco
Work Type
- Hybrid
- Onsite
Experience Level
- Principal Scientist
- Associate Director
Education Level
- PhD
- MS