Sr Staff Program Manager, MES Custom Software Development Transformation
Twist Bioscience · CA, US
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About the Role
Twist Bioscience is seeking an experienced Sr Staff Program Manager to drive the strategic planning, cross-functional coordination, and execution of a critical MES transformation initiative. This role will lead the delivery of MES replatform efforts, bringing structure, Agile discipline, and program governance to ensure successful execution.
Responsibilities
- Lead the overall MES replatform transformation, translating strategic objectives into an actionable, integrated program roadmap.
- Lead day-to-day execution of the MES replatform, managing timelines, scope, resources, and deliverable milestones.
- Partner with business users, IT process owners, and external software vendors/agencies to communicate status, align expectations, and resolve cross-functional issues.
- Track project expenditures, support financial budgeting, and ensure efficient resource allocation across core initiative tracks.
- Implement company and departmental procedures that affect immediate operations.
- Assist with organizational change management to ensure smooth system adoption and transition from legacy platforms.
- Proactively identify technical, operational, and integration risks.
- Enforce quality-control practices, compliance standards, and validation protocols required in manufacturing software environments.
Requirements
- Bachelor’s degree in Computer Science, Software Engineering, Industrial Engineering, Information Technology, or a related field.
- Minimum of 12 years of experience performing and improving business processes, with a strong focus on manufacturing, life sciences, engineering, or operations.
- Proven expertise in Agile project delivery frameworks.
- 5 plus years in project or program management leading cross-functional custom software development teams.
- Solid hands-on understanding of the custom software development lifecycle (SDLC), modern software architecture principles, and business transformation frameworks.
- Strong leadership, negotiation, and conflict-resolution skills.
- Track record of translating complex manufacturing requirements into actionable software solutions.
- Biotech or pharmaceutical industry experience is preferred.
- Specialized experience in biotech, pharmaceutical, semiconductor, or advanced discrete manufacturing environments.
- Deep understanding of custom software development lifecycles (SDLC), shop-floor manufacturing processes, SCADA/PLC integration, and ISA-95 standards.
Skills
- Agile project delivery frameworks
- Scrum Master
- SAFe
- PMI-ACP
- Facilitating Agile ceremonies
- Managing iteration cycles
- Custom software development lifecycle (SDLC)
- Modern software architecture principles
- Business transformation frameworks
- Leadership
- Negotiation
- Conflict-resolution
- Shop-floor manufacturing processes
- SCADA/PLC integration
- ISA-95 standards
Location
- South San Francisco, CA
- Wilsonville, OR
Work Type
- Hybrid
Experience Level
- Sr Staff
- Minimum of 12 years of experience
- 5 plus years in project or program management
Education Level
- Bachelor’s degree
Salary/Compensations
- $233,000—$271,000 USD
Benefits
- Bonus
- Equity
- Generous benefits package
About the Company
- Twist Bioscience synthesizes genes from scratch, known as “writing” DNA.
- At Twist Bioscience, we work in service of people who are changing the world for the better.
- In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.
Equal Opportunity
- Twist Bioscience Corporation is an Equal Opportunity Employer.
- Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.