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About the Role

We are seeking a highly collaborative, hands-on Senior Scientist I to establish a preclinical neuroscience laboratory supporting small-molecule and protein therapeutics. The role will focus on cellular profiling, lead selection, and building neuronal models and laboratory workflows.

Responsibilities

Lead a rapid, tiered cellular assay strategy for small-molecule lead optimization.
Lead cellular development of a transferrin-based protein replacement project by establishing quantitative assays.
Use orthogonal methods to distinguish surface-bound, internalized, degraded, and functionally delivered protein.
Establish fit-for-purpose neuronal culture models, including iPSC-derived neurons or glia.
Define assay controls, acceptance criteria, reproducibility standards, analysis plans, SOPs, sample tracking, and electronic documentation.
Translate data into concise recommendations to advance, modify, or discontinue assets.
Partner across protein engineering, chemistry, bioanalysis, DMPK, pathology, computational biology, and in vivo pharmacology.
Scientifically manage CROs and assay transfers.
Mentor junior scientists and build workflows that are reproducible across operators.
Future scope may include ASO screening in partnership with external experts.

Requirements

PhD in pharmacology, neuroscience, molecular biology, chemical biology, cell biology, or a related discipline.
3 to 6 years of biotechnology or pharmaceutical industry experience.
Demonstrated experience in cellular pharmacology, assay development, and iterative drug discovery or lead optimization.
Hands-on experience with neuronal cell culture models, preferably human iPSC-derived neurons or glia.
Expertise in concentration-response, time-course, target-engagement, pharmacodynamic, quantitative data-analysis, and troubleshooting studies.
Concrete examples of scientific ownership in which an assay, platform, or data package influenced a program decision.
Excellent communication skills and willingness to maintain a substantial hands-on laboratory presence.

Skills

Enzyme biology
Epigenetics
Transcriptional pharmacology
Therapeutic proteins
Targeted-delivery constructs
Cellular uptake
Trafficking
Protein quantification
Mitochondrial functional assays
High-content imaging
Neuronal functional assays
Transferrin receptor biology
BBB transport
Biodistribution
Laboratory start-up
Assay transfer
CRO management
ASO screening
RNA pharmacology

Location

Northeast
Mid-Atlantic

Work Type

Hands-on laboratory presence

Experience Level

Senior Scientist I
3 to 6 years of biotechnology or pharmaceutical industry experience

Education Level

PhD in pharmacology, neuroscience, molecular biology, chemical biology, cell biology, or a related discipline

Salary/Compensations

$143,500 - $160,000 a year

About the Company

Lexeo Therapeutics is a New York City-based, clinical stage company dedicated to reshaping the path of genetic disease.
By advancing pioneering science, Lexeo seeks to set a new standard in the treatment of cardiovascular and neurological genetic diseases, charting the path to patient outcomes once thought out of reach.
The Company is advancing a portfolio of therapeutic candidates designed to address the underlying genetic causes of disease, including LX2006 for Friedreich ataxia (FA), LX2020 for plakophilin-2 (PKP2) arrhythmogenic cardiomyopathy, and others in devastating diseases with high unmet need.

Equal Opportunity

LEXEO Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.