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About the Role
We are seeking a Principal Scientist with a strong background in immunology to identify new therapeutic opportunities and help shape Xaira’s portfolio. You will integrate internal datasets, human genetics, and published research to prioritize opportunities that address patient needs and build on Xaira’s target discovery and antibody design platforms. This role is ideal for someone who enjoys connecting scientific findings and translating them into strategic decisions.
Responsibilities
- Identify promising disease areas by assessing unmet needs, disease mechanisms, patient subsets, and treatment limitations.
- Find and prioritize targets by combining human genetics, functional genomics, genome-scale multi-omics datasets, and patient data to develop therapeutic hypotheses.
- Assess platform fit by working with molecular design, protein engineering, and functional screening teams to identify opportunities where our platforms offer a therapeutic advantage.
- Evaluate evidence by assessing causality, desired target modulation, safety risks, and knowledge gaps.
- Build clear recommendations, including disease rationale, patient selection, competition, differentiation, and risks.
- Track emerging science and competition by following publications, clinical results, and monitoring the competitive landscape.
- Use AI tools to analyze multi-modal data.
- Lead discovery programs or platform initiatives.
Requirements
- PhD in immunology or a related field.
- 6+ years of industry experience in drug discovery, target discovery, preclinical drug development, or translational drug development.
- Experience drawing on human genetics, genome-scale multi-omics datasets, and other human data alongside cell biology, disease biology, and clinical findings to evaluate therapeutic hypotheses.
- Strong scientific judgment and the ability to distinguish an interesting association from a credible therapeutic opportunity.
- Clear communication skills and the ability to guide decisions across disciplines.
- Curiosity, independence, and a willingness to challenge assumptions and revise recommendations as the evidence evolves.
Skills
- Immunology
- Drug discovery
- Target discovery
- Preclinical drug development
- Translational drug development
- Human genetics
- Genome-scale multi-omics datasets
- Cell biology
- Disease biology
- Clinical findings
- Therapeutic hypothesis evaluation
- Scientific judgment
- Communication skills
- AI tools
- Multi-modal data analysis
Location
- San Francisco Bay Area
- Seattle
- London
Work Type
- Full-time
Experience Level
- Principal Scientist
- 6+ years of industry experience
Education Level
- PhD in immunology or a related field
Salary/Compensations
- $164,000-$205,000 annually
Benefits
- Competitive compensation and benefits package
- Open, flexible, and friendly work environment
- Platform for long-term career development
- Summary of Benefits available
- Base salary
- Bonus
- Equity
About the Company
- Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development.
- The company is leading the development of generative AI models to design protein and antibody therapeutics, enabling the creation of medicines against historically hard-to-drug molecular targets.
- It is also developing foundation models for biology and disease to enable better target elucidation and patient stratification.
- Collectively, these technologies aim to continually enable the identification of novel therapies and to improve success in drug development.
- Xaira is headquartered in the San Francisco Bay Area, Seattle, and London.
Equal Opportunity
- Xaira Therapeutics an equal-opportunity employer.
- We believe that our strength is in our differences.
- Our goal to build a diverse and inclusive team began on day one, and it will never end.