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About the Role
Assist with characterising how receptors bind to hormone targets using label-free biophysical instruments. Focus on ligand kinetics screening to select and refine receptors for real-time, continuous biosensors. Requires careful experimental technique and attention to detail due to challenging small molecule targets.
Responsibilities
- Run binding experiments on receptor-hormone interactions using GCI, SPR and ITC, following established methods.
- Prepare samples, buffers and sensor chips, and maintain instruments to keep data quality consistent.
- Measure binding kinetics (on-rates and off-rates) and affinity, and spot and flag common data artefacts.
- Troubleshoot routine issues such as non-specific binding and carry-over, working with the team to optimise buffers, additives and cleaning protocols.
- Support method refinement for difficult, poorly soluble targets.
- Run assays in realistic biological samples to help assess how other components affect results.
- Document methods and results clearly, and share findings with the wider team.
Requirements
- 1-2 years of hands-on experience running biophysical characterisation instruments (SPR, GCI, ITC or BLI).
- Experience with protein or small-molecule binding studies and basic kinetic analysis.
- Awareness of common pitfalls in small-molecule binding, such as mass transport effects and solvent correction.
- Strong attention to detail, careful record-keeping and a methodical approach to troubleshooting.
- Experience with aptamers or other nucleic acid-small molecule interactions, hydrophobic targets, complex sample matrices, or ITC is a bonus.
- Ability to live and breathe integrity, tackling challenges with honesty and transparency.
- Ability to be a self-starter who loves diving into the unknown, collaborating on complex problems, and taking full ownership of results.
- Ability to excel at open, clear communication and see every piece of feedback as a springboard for growth.
- Motivation by creating real impact, particularly when it comes to advancing human health.
- Ability to strike a balance between independence and collaboration.
- Ability to be confident in defending your ideas, while also valuing respectful, constructive debate.
- Ability to thrive in the dynamic atmosphere of a startup, constantly evolving your skill set and fearlessly applying what you learn.
Skills
- Label-free biophysical instruments
- SPR
- GCI
- BLI
- ITC
- Ligand kinetics screening
- Receptor-hormone interactions
- Sample preparation
- Buffer preparation
- Sensor chip maintenance
- Binding kinetics analysis
- Affinity measurement
- Data artefact identification
- Troubleshooting
- Method optimisation
- Assay development
- Data documentation
- Protein binding studies
- Small-molecule binding studies
- Kinetic analysis
- Mass transport effects
- Solvent correction
- Aptamers
- Nucleic acid-small molecule interactions
- Hydrophobic targets
- Complex sample matrices
- Collaboration
- Curiosity
- Integrity
- Communication
- Problem-solving
- Adaptability
Location
- New York
Work Type
- Full-time
Experience Level
- 1-2 years
Salary/Compensations
- Competitive salary and equity options
Benefits
- Equity options
- Collaboration with founding team
- Access to industry experts and thought leaders
- Opportunities for leadership and career advancement
- Travel to New York and other potential sites for R&D purposes
- Work on cutting-edge technology
- Shape strategic decisions
- Drive innovation at an early-stage venture
About the Company
- Pioneering next-generation biosensor technology for precise, real-time monitoring of critical endocrine biomarkers.
- Recognised as one of the top 20 startups across all categories worldwide at TechCrunch Disrupt 2024.
- Backed by top-tier organisations like SOSV and Entrepreneur First.
- Pushing the boundaries of biochemistry and nanotechnology to revolutionize personalised health.
- Founded by seasoned engineers with extensive experience in R&D, technical innovation, and commercial strategy.
- Mission to revolutionise health management by delivering clinical-grade data directly to individuals.
- Assembling a team dedicated to turning cutting-edge science into life-changing, real-world solutions.