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About the Role
The Department of Pathology at Albert Einstein College of Medicine is seeking a Research Technician D to join a multidisciplinary research team studying breast cancer progression and metastasis. The laboratory utilizes a combination of techniques including cancer cell biology, mouse models, advanced imaging, microfluidics, and single-cell approaches to understand how tumor cells disseminate, survive, and establish metastatic disease. The successful candidate will contribute to multiple NIH- and foundation-funded projects focused on breast cancer metastasis, cancer stem-cell biology, tumor-macrophage interactions, mechanotransduction, and early-stage breast cancer progression. This position is ideal for an experienced experimentalist capable of independent work, troubleshooting, protocol development, and collaboration.
Responsibilities
- Maintain and experimentally manipulate mammalian cancer cell lines, including generation of engineered cell lines using transfection and viral transduction.
- Perform flow cytometry/FACS, tissue dissociation, cell isolation, and preparation of high-quality single-cell suspensions for downstream analyses including single-cell RNA sequencing.
- Perform molecular and cellular biology techniques including DNA/RNA/protein isolation, PCR/qPCR, immunofluorescence, immunohistochemistry, and related assays.
- Conduct functional cell-based experiments including migration, invasion, transwell, fluorescent reporter, and other assays relevant to cancer-cell behavior.
- Prepare and process cells and tissues from mouse experiments and assist with animal handling, injections, tumor monitoring, tissue collection, and related procedures.
- Support multiplexed fluorescence imaging and other quantitative microscopy-based studies.
- Independently troubleshoot experiments, modify or optimize technical procedures and experimental protocols, and analyze and interpret resulting data.
- Maintain mouse colonies, including genotyping, phenotyping, and breeding.
- Maintain accurate experimental records, organize samples and datasets, manage laboratory reagents and supplies, monitoring and changing liquid nitrogen tanks for dewars, and help train or guide other laboratory members.
- Contribute to preparation of figures, methods, presentations, manuscripts, and other scientific materials as appropriate.
- Routinely modify technical procedures.
- Routinely train or guide other lab members.
- May routinely operate, maintain and troubleshoot complex, high tech equipment.
- Routinely modify/formulate experimental protocols.
- Routinely analyze and interpret data.
- May make frequent written contributions to papers and grant proposals.
- An in-depth understanding of complex scientific literature and an extensive understanding of research goals and rationale is required.
Requirements
- Bachelor’s or Master’s degree in biology, molecular biology, cell biology, biochemistry, cancer biology, or a related scientific discipline, or equivalent skills and experience.
- At least 4.5 years of relevant laboratory research experience.
- Strong experience with mammalian cell culture and molecular/cellular biology techniques.
- Demonstrated ability to work independently.
- Demonstrated ability to troubleshoot experimental problems.
- Demonstrated ability to maintain rigorous and reproducible records.
- Demonstrated ability to manage multiple concurrent experiments.
- Demonstrated ability to communicate effectively as part of a collaborative research team.
Skills
- Mammalian cell culture
- Molecular biology techniques
- Cellular biology techniques
- Flow cytometry/FACS
- Transfection
- Viral transduction
- Tissue dissociation
- Fluorescence-based assays
- Cancer biology
- Tumor microenvironment
- Immune-cell biology
- Mouse models
- Preparation of samples for single-cell sequencing
- Quantitative microscopy
- Experimental troubleshooting
- Record keeping
- Data management
- Reagent and supply management
- Scientific writing
- Data analysis
- Data interpretation
Location
- New York City
Work Type
- Full-time
Experience Level
- 4.5+ years of relevant laboratory research experience
Education Level
- Bachelor's or Master's degree in biology, molecular biology, cell biology, biochemistry, cancer biology, or a related scientific discipline, or equivalent skills and experience
Salary/Compensations
- $38.99/hour (Hiring Rate)
- $39.52/hour (Post Probationary Rate)
- $41.17/hour (Job Rate)
About the Company
- The Department of Pathology at Albert Einstein College of Medicine is seeking a highly motivated and experienced Research Technician D to join a multidisciplinary research team studying breast cancer progression and metastasis.
- Our laboratory combines cancer cell biology, mouse models, advanced imaging, microfluidics, and single-cell approaches to understand how tumor cells disseminate, survive, and establish metastatic disease.
- The successful candidate will contribute to multiple NIH- and foundation-funded projects focused on breast cancer metastasis, cancer stem-cell biology, tumor-macrophage interactions, mechanotransduction, and early-stage breast cancer progression.