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About the Role

Amgen is seeking a Senior Scientist, Integrated Computational and Experimental Inflammation Discovery to advance Inflammation discovery programs by leading scientific activities, generating evidence, and applying innovative technologies to deepen disease understanding and inform therapeutic hypotheses. This role involves iterating between bench experimentation and computational workflows, contributing to target program teams and technology development.

Responsibilities

Independently design, execute, analyze, and interpret bench/wet-lab experiments that address critical biological questions, test therapeutic hypotheses, and support target identification, validation, and progression.
Apply advanced experimental, computational, AI-enabled, and data-analytic approaches to generate mechanistic insight, improve experimental design, and integrate findings across data sources.
Develop decision criteria and provide evidence-based recommendations for target and program go/no-go decisions.
Lead activities within work groups and project teams, coordinating contributions from multiple disciplines to achieve program objectives.
Develop and implement novel scientific approaches, technologies, and workflows that improve efficiency, rigor, translational relevance, and probability of success in discovery programs.
Build expertise in small- and large-molecule drug discovery and apply this knowledge to support high-caliber biological research and therapeutic strategy in Inflammation.
Proactively develop and optimize solutions to complex scientific or technical problems within area of expertise using ingenuity, creativity, and current scientific knowledge.
Coach and provide scientific or technical guidance to colleagues within work groups and project teams, contributing to a connected, inclusive culture of scientific excellence.
Organize, interpret, adapt, and communicate project data and scientific recommendations across projects, functions, and internal scientific forums; contribute to external scientific communications where appropriate.
Contribute to scientific publications, presentations, patents, technical reports, and other documents that expand organizational knowledge and advance portfolio impact.

Requirements

Doctorate degree PhD, PharmD, MD [and relevant post-doc where applicable], Master’s degree and 3 years of relevant scientific experience, or Bachelor’s degree and 5 years of relevant scientific experience.
Advanced and proficient understanding of technical principles, theories, and concepts relevant to inflammation, immunology, disease biology, and drug discovery.
Demonstrated ability to work independently under minimal direction, determine methods and procedures for new assignments, and make independent scientific decisions within a work group or function.
Experience leading scientific activities within project teams or work groups and contributing to multidisciplinary teams at the functional, departmental, or therapeutic-area level.
Strong track record designing, executing, analyzing, and interpreting experimental studies that support target discovery, validation, translational biology, or therapeutic hypothesis testing.
Experience applying computational biology, AI-enabled scientific tools, advanced data analytics, multimodal data integration, or predictive modeling to improve discovery research.
Ability to proactively develop novel processes, technologies, workflows, or scientific approaches to solve complex problems and improve project outcomes.
Experience coaching, mentoring, or providing scientific and technical advice to colleagues within work groups or project teams.
Strong written and verbal communication skills, including the ability to organize, interpret, adapt, and present scientific or technical information across projects and functions.
Contributions to scientific or technical documents such as posters, presentations, publications, regulatory documents, patent applications, technical reports, or internal governance materials.
Basic knowledge of related and adjacent disciplinary areas, such as translational science, human genetics, clinical biology, computational biology, protein engineering, small-molecule discovery, or therapeutic development.

Skills

Inflammation
Immunology
Disease biology
Drug discovery
Computational biology
AI-enabled scientific tools
Advanced data analytics
Multimodal data integration
Predictive modeling
Small-molecule drug discovery
Large-molecule drug discovery
Scientific communication

Location

Work Type

Flexible work models where possible

Experience Level

Senior Scientist

Education Level

Doctorate degree PhD
PharmD
MD
Master’s degree
Bachelor’s degree

Salary/Compensations

131,028.35USD -177,273.65 USD

Benefits

Comprehensive employee benefits package
Retirement and Savings Plan with generous company contributions
Group medical, dental and vision coverage
Life and disability insurance
Flexible spending accounts
Discretionary annual bonus program
Stock-based long-term incentives
Award-winning time-off plans

About the Company

Amgen is a biotechnology company that has been pioneering the biotech industry since 1980, fighting against the world's toughest diseases.
Amgen is advancing a broad and deep pipeline and portfolio of medicines to treat heart disease, obesity and obesity-related conditions, rare diseases, inflammatory conditions and cancer.
Amgen's award-winning culture is collaborative, innovative, and science based.
Amgen fosters an inclusive environment of ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients.

Equal Opportunity

Amgen is an Equal Opportunity employer. We make all employment decisions without regard to race, color, religion, sex or any other characteristic protected by applicable law.
We provide reasonable accommodations to applicants and employees with disabilities, consistent with legal requirements.
Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.