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About the Role
Join Cartography Biosciences' Pharmacology team as an Associate Scientist, focusing on the in vitro development and characterization of novel T cell engagers. This lab-based role involves high-throughput functional screening and secondary characterization assays.
Responsibilities
- Execute high-throughput in vitro screening assays for T cell engagers, including in vitro cytotoxicity.
- Perform characterization assays, such as flow cytometry.
- Maintain and expand primary cell culture (PBMCs, primary T cells) and cancer cell line culture.
- Design, execute, and troubleshoot assays independently and collaboratively.
- Maintain accurate records in the electronic lab notebook (ELN) and contribute to SOP development and assay documentation.
- Analyze, visualize, and interpret experimental data using tools like FlowJo, GraphPad Prism, and Excel.
- Contribute to general lab operations, including reagent preparation, equipment maintenance, and inventory management.
- Summarize and present experimental results and progress updates at team meetings.
Requirements
- Master's/Bachelor's degree in Biology or a related scientific field.
- 3+ years of relevant hands-on laboratory experience in academia or industry.
- Proficiency in tissue culture, including primary cell culture (e.g., PBMCs, primary T cells) and cancer cell line maintenance.
- Experience in T cell biology and in vitro functional assays.
- Hands-on experience with flow cytometry.
- Strong analytical skills for independent data analysis, interpretation, and troubleshooting.
- Excellent organizational skills, attention to detail, and accurate record-keeping (ELN).
- Self-motivated, adaptable, and proactive in a fast-paced environment.
- Demonstrated team player with a professional and positive attitude.
- Strong written and oral communication skills.
- Ability to be on-site and in person 5 days a week.
- Experience working with T cell engagers is strongly preferred.
- Familiarity with TDCC and on-cell binding assays.
- Experience with data analysis software such as FlowJo and GraphPad Prism.
Skills
- T cell biology
- In vitro assay development
- MoA studies
- High-throughput screening
- Flow cytometry
- Primary cell culture
- Cancer cell line maintenance
- Assay design
- Assay execution
- Assay troubleshooting
- Electronic lab notebook (ELN)
- SOP development
- Assay documentation
- Data analysis
- Data visualization
- Data interpretation
- GraphPad Prism
- Excel
- TDCC
- On-cell binding assays
- FlowJo
Location
- South San Francisco, CA
Work Type
- On-site
- Full-time
Experience Level
- Associate Scientist
- 3+ years of relevant hands-on laboratory experience
Education Level
- Master's degree in Biology or related scientific field
- Bachelor's degree in Biology or related scientific field
About the Company
- Cartography Biosciences is seeking a highly motivated Associate Scientist to join our Pharmacology team and play a pivotal role in the in vitro development and characterization of novel T cell engagers across our pipeline.