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About the Role
As a part of the Protein Analytics team, you will play a crucial role in discovering and developing novel biotherapeutics. The ideal candidate will have extensive experience characterization of monoclonal and bi/multispecific antibodies within a biotherapeutics discovery setting, coupled with a proactive and can-do attitude. This is a hands-on, lab-based position.
Responsibilities
- Support the discovery and development of therapeutic molecules through hands-on laboratory work.
- Characterize antibodies in high-throughput manner via biolayer interferometry (BLI) and surface plasmon resonance (SPR) based biosensor platforms to determine Yes/No binding, Kinetics and Affinity information.
- Screen antibodies and other antibody-like molecules for off-target binding assessment via BVP ELISA or other poly-specificity/poly-reactivity assays.
- Perform early developability assessment on antibody panels using SPR, DLS, DSF, SEC and ELISA platforms.
- Support other workflows as needed, including fluorescence based binding assays and assay automation.
- Analyze experimental data, curate results and reports, and present findings to cross-functional teams.
- Maintain experimental records in an ELN.
- Ensure compliance with laboratory safety protocols and contribute to lab organization and operations.
Requirements
- PhD degree in a relevant discipline with 5+ years of industry experience or a BS/MS degree with 10+ years of industry experience in biophysics, biochemistry, structural biology, or a related discipline
- Extensive experience in antibody screening including monoclonals, bispecific, and other antibody-like molecules.
- Extensive hands-on experience with ELISA, BLI and SPR based platforms (Carterra, Biacore).
- Basic knowledge of protein production, purification and characterization techniques (including affinity, ion exchange, HIC, DLS, DSF and SEC).
- Proficiency in data analysis software (e.g., GraphPad Prism) and other statistical tools.
- Proactive attitude with a self-starter mindset.
- Strong organizational, communication, and interpersonal skills.
- Strong collaborative skills and interest in working in cross-functional teams and a startup environment.
- Excellent problem-solving and troubleshooting abilities.
- Ability to work independently with accountability and meticulous attention to detail.
Skills
- ELISA
- BLI
- SPR
- DLS
- DSF
- SEC
- GraphPad Prism
Location
- San Francisco Bay Area
- Seattle
- London
Work Type
- Lab-based
- Startup environment
Experience Level
- 5+ years of industry experience (PhD)
- 10+ years of industry experience (BS/MS)
- Candidates with fewer years of experience are also encouraged to apply, and the leveling of the role can be adjusted if needed
Education Level
- PhD degree in a relevant discipline
- BS/MS degree in biophysics, biochemistry, structural biology, or a related discipline
Salary/Compensations
- $136,000 - $170,000 annually
Benefits
- Competitive compensation and benefits package
- Open, flexible, and friendly work environment
- Platform to develop long-term careers
- Summary of Benefits is available for all applicants
- Base salary, bonus, and equity
About the Company
- Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development.
- The company is leading the development of generative AI models to design protein and antibody therapeutics, enabling the creation of medicines against historically hard-to-drug molecular targets.
- It is also developing foundation models for biology and disease to enable better target elucidation and patient stratification.
- Collectively, these technologies aim to continually enable the identification of novel therapies and to improve success in drug development.
Equal Opportunity
- Xaira Therapeutics an equal-opportunity employer.
- We believe that our strength is in our differences.
- Our goal to build a diverse and inclusive team began on day one, and it will never end.