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About the Role
We are seeking a Principal/AD Medicinal Chemist to lead and advance small molecule drug discovery programs from early hit identification through IND-enabling studies. This is a senior, hands-on scientific leadership role requiring deep expertise in medicinal chemistry, strategic thinking, and cross-functional collaboration. The candidate will direct work to be completed at a CRO. This position calls for a highly creative and experienced chemist who can independently design and execute medicinal chemistry strategies while contributing to the integration of computational and AI-driven approaches into drug discovery workflows. The ideal candidate will combine strong technical depth with the ability to guide internal teams and external partners toward impactful outcomes.
Responsibilities
- Propose and independently drive medicinal chemistry strategies to progress programs from hit identification through lead optimization to development candidate selection
- Lead chemistry efforts within cross-functional project teams, which include bench biologists, DMPK lead, non-clinical tox lead, computational scientists, ML engineers
- Design, prioritize, and guide synthesis of novel compounds using structure-based and ligand-based approaches to optimize potency, selectivity, pharmacokinetics and developability
- Interpret and integrate SAR, structural biology, DMPK, pharmacology, and safety data to drive compound design and progression
- Contribute to and integrate AI-driven and computational modeling insights into compound design strategies
- Serve as a technical leader and mentor for internal chemists and external collaborators
- Manage external CRO partnerships to ensure high-quality and timely delivery of chemistry objectives
- Communicate program strategy, data, risks, and recommendations to senior leadership
- Author and contribute to patent strategies and applications, scientific publications, and internal reports
Requirements
- Applicants must be authorized to work for any employer in the U.S. We are unable to sponsor or take over sponsorship of an employment Visa at this time.
- PhD in Organic Chemistry or a related field with 3-8 years of industry experience in medicinal chemistry
- Proven track record of advancing drug discovery programs through key milestones (Hit-to-Lead and Lead Optimization)
- Deep expertise in synthetic organic chemistry, including modern methods and reaction mechanisms
- Strong experience in structure-based and ligand-based drug design
- Demonstrated ability to optimize compounds for potency, selectivity, and DMPK/safety properties
- High level of creativity, productivity, and independent problem-solving ability
- Experience managing external CROs and collaborating across disciplines
- Excellent communication skills with the ability to clearly present complex scientific concepts
Skills
- Medicinal Chemistry
- Synthetic Organic Chemistry
- Structure-based Drug Design
- Ligand-based Drug Design
- Computational Chemistry
- AI-driven Design
- Predictive Toxicology
- ADMET Modeling
- Cheminformatics
- Data Science
Location
- U.S.
Work Type
- Remote-friendly
- Flexible working structure
Experience Level
- Principal/AD
- 3-8 years of industry experience
Education Level
- PhD in Organic Chemistry or a related field
Salary/Compensations
- Competitive compensation aligned with market benchmarks
Benefits
- Equity participation reflecting long-term impact
About the Company
- Deep Origin is a biotechnology company building an operating system for science that transforms how life science research is conducted.
- Our AI-powered platforms simulate biology, streamline R&D workflows, and enable scientists to model complex biological systems at scale.
- As part of strategic government-backed initiatives and the expansion of our AI-driven simulation infrastructure, we are scaling our capabilities in whole-human modeling and predictive toxicology.
- Exceptional modeling talent is a critical lever in accelerating our mission to reduce disease and extend human health span.