Postdoctoral Research Associate, Cardiocvascular Research
City St George's, University of London · GB
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About the Role
Seeking a postdoctoral researcher to join the Cardiovascular Research Institute at City St. George’s, University of London, a world-leading centre for investigating the causes of sudden cardiac death in the young. This 18-month post is funded by a Springboard grant from the Academy of Medical Sciences and British Heart Foundation. The project aims to characterise and validate novel genes for Brugada syndrome using zebrafish models.
Responsibilities
- Design CRISPR-mediated gene knockdown of zebrafish orthologues for novel putative Brugada genes.
- Undertake functional analyses to assess the effect of these knockdowns on heart function.
- Implement new techniques and optimize protocols critical to the project.
- Provide technical expertise and input for troubleshooting of experiments.
- Work with limited supervision.
- Contribute to data analysis and interpretation.
Requirements
- PhD in molecular biology, cellular biology, biochemistry or a related discipline.
- Practical expertise with gene editing methodologies.
- Extensive direct experience of zebrafish husbandry techniques.
- Experience in the development of zebrafish disease models.
- Experience in designing and executing functional assays for evaluating the effects of gene mutations.
- Excellent technical and problem-solving skills.
- Ability to work effectively in a multi-disciplinary team.
Skills
- Gene editing methodologies
- Zebrafish husbandry techniques
- Zebrafish disease models
- Functional assays
- CRISPR-mediated gene knockdown
Location
- City St George’s, University of London
Work Type
- Permanent contract subject to fixed-term funding
- Full-time
Experience Level
- Postdoctoral researcher
Education Level
- PhD
About the Company
- City St George’s, University of London is the University of business, practice and the professions and brings together the expertise and excellence of City, University of London and St George’s, University of London into one institution.
- The combined university is now one of the largest higher education destinations for London students, combining a breadth of disciplines across health, business, policy, law, creativity, communications, science and technology.
- Our students are at the heart of everything that we do, and we are committed to supporting them to pursue their career and personal ambitions.
- Our research is engaged, at the frontier of practice and has a positive impact on the world around us.
Equal Opportunity
- City St George’s, University of London is committed to promoting equality, diversity and inclusion in all its activities, processes, and culture for our whole community, including staff, students and visitors.
- We welcome applications regardless of age, caring responsibilities, disability, gender identity, gender reassignment, marital status, nationality, pregnancy, race and ethnic origin, religion and belief, sex, sexual orientation and socio-economic background.
- City St George’s operates a guaranteed interview scheme for disabled applicants.