Sr Bioinformatics Scientist at Twist Bioscience | CA, US | Rezi

Sr Bioinformatics Scientist at Twist Bioscience

Sr Bioinformatics Scientist

Twist Bioscience · CA, US

1 months ago

Sr Bioinformatics Scientist

Twist Bioscience · CA, US

a month ago
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About the Role

Twist Bioscience is seeking a Senior Bioinformatics Scientist to join the Scientific Computing team, supporting R&D in DNA Synthesis and Protein Solutions. This role involves developing computational methods and predictive models to analyze biological data, guide product development, and enhance scientific workflows. You will collaborate with scientists to address complex challenges in sequencing, DNA synthesis, and protein characterization, contributing to algorithm development, hypothesis testing, and workflow building.

Responsibilities

  • Develop novel computational methods and algorithms supporting DNA synthesis, sequence analysis, and protein characterization.
  • Partner with experimental scientists to formulate hypotheses, design experiments, and interpret results that guide product and process development.
  • Analyze NGS and other experimental datasets to identify biological patterns, understand sources of variability, and investigate unexpected outcomes.
  • Apply statistical methods, machine learning, and predictive modeling to connect sequence and experimental features with product quality and performance.
  • Evaluate and validate analytical approaches, including their accuracy, limitations, and applicability across experimental conditions.
  • Develop reproducible analysis pipelines using Nextflow and other scientific computing tools to support research and method evaluation.
  • Communicate findings and recommendations to scientific and cross-functional stakeholders, and collaborate with engineers to translate successful methods into broader use.
  • Explore new technologies and analytical approaches as research priorities evolve.

Requirements

  • Ph.D. with 3+ years, Master’s degree with 6+ years, or Bachelor’s degree with 8+ years of relevant experience in bioinformatics, computational biology, biostatistics, or a related field; equivalent combinations of education and experience will be considered.
  • Strong Python programming skills and experience analyzing biological or experimental data.
  • Hands-on experience with NGS analysis and a solid understanding of molecular biology.
  • Experience developing and evaluating computational algorithms, statistical methods, or predictive models.
  • Strong foundation in statistics, experimental design, and critical interpretation of scientific results.
  • Experience building reproducible analysis workflows using Nextflow or a comparable tool.
  • Demonstrated ability to independently investigate scientific problems and learn unfamiliar methods or biological domains.
  • Ability to collaborate closely with experimental scientists and communicate complex findings clearly.

Skills

  • Python programming
  • NGS analysis
  • Molecular biology
  • Computational algorithms
  • Statistical methods
  • Predictive modeling
  • Statistics
  • Experimental design
  • Nextflow
  • Protein data analysis
  • DNA synthesis
  • Sequence design
  • Machine learning
  • Cloud computing

Location

  • San Francisco Bay Area

Work Type

  • Full-time

Experience Level

  • Senior

Education Level

  • Ph.D.
  • Master’s degree
  • Bachelor’s degree

Salary/Compensations

  • $135,000—$173,000 USD

Benefits

  • Bonus
  • Equity
  • Generous benefits package

About the Company

  • Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers, serving fields such as health care, agriculture, industrial chemicals, and data storage.

Equal Opportunity

  • Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.