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About the Role

The Goodman Lab for Synthetic Immunology is seeking highly motivated candidates interested in synthetic biology, cell therapy, and immunoengineering to join their founding team. The lab focuses on high-throughput genetic manipulation and measurement of primary immune cell populations to improve cellular immunotherapies for cancer and other diseases. The specialist will apply cutting-edge approaches, set up lab protocols, and perform experimental techniques such as molecular cloning, cell culture, flow cytometry, and DNA library preparation for high throughput sequencing. This position offers extensive hands-on experience in biomedical research.

Responsibilities

Drive a research project by performing various investigative procedures, including collecting, analyzing, and interpreting data, and presenting findings at group meetings.
Collect, record, organize, and verify the accuracy of data; perform calculations and prepare charts, graphs, and reports.
Assist in the general running of the lab, including receiving items, generating protocols, and maintaining lab organization.
Become familiar with the scientific literature and participate in group meetings.
Perform other duties and responsibilities as assigned.

Requirements

Bachelor of Science and 0 to 1 year of experience or equivalent combination of education and experience is required for Research Specialist A.
Bachelor’s degree in a relevant discipline and 1-3 years of relevant research experience or an equivalent combination of education and experience is required for Research Specialist B.
Willingness and ability to work independently, learn new methods, and be engaged as part of a research team.
Excellent skills in communication, organization, and time management.
For Research Specialist B, demonstrate a higher level of independent work, including designing, troubleshooting, and optimizing experiments related to T cell engineering and synthetic immunology.
For Research Specialist B, analyze and interpret experimental data with minimal supervision.
For Research Specialist B, contribute to manuscript preparation, presentations, and grant submissions.
Background checks may be required after a conditional job offer is made.

Skills

Synthetic biology
Cell therapy
Immunoengineering
Molecular cloning
Cell culture (cell lines and primary cells)
Flow cytometry
Preparation of DNA libraries for high throughput sequencing
Immunology
Molecular biology
Organizational skills
Communication skills
Time management skills
Prior research experience in a related field (e.g., synthetic biology, systems biology, immunology, bioengineering, chemical biology, molecular biology, cell biology)
Experience with the culture of mammalian cells (e.g., tumor cell lines, PBMCs, primary T cells)
Experience in the design and assembly of DNA constructs (modern molecular cloning techniques such Golden Gate or Gibson Assembly)
Experience preparing RNA and DNA high-throughput sequencing libraries (e.g. Illumina, 10X Genomics)
Experience in flow cytometry or cell sorting
Experience handling mice and performing experiments using in vivo mouse models of disease, especially cancer models
Experience with bioinformatics pipelines and visualization tools (e.g. Python and R)

Location

Philadelphia, Pennsylvania

Work Type

Full-time

Experience Level

0-1 year of experience (Research Specialist A)
1-3 years of relevant research experience (Research Specialist B)

Education Level

Bachelor of Science
Bachelor’s degree in a relevant discipline

Salary/Compensations

$45,278.00 - $57,335.40 Annual Rate

Benefits

Comprehensive medical, prescription, behavioral health, dental, vision, and life insurance benefits.
Flexible spending accounts for eligible health care and dependent care expenses.
Tuition assistance for employees, spouses, and dependent children at Penn and potentially other institutions.
Generous retirement plans (Basic, Matching, and Supplemental) with pre-tax or Roth options and investment choices through TIAA and Vanguard.
Substantial time away from work for vacation, personal affairs, illness, or family needs.
Long-term care insurance options.
Wellness and work-life resources and programs.
Professional and personal development resources.
Access to University resources, cultural activities, and recreational facilities.
Discounts and special services on arts, entertainment, transportation, mortgages, and more.
Flexible work hours and options.
Home ownership assistance program (forgivable loan).
Adoption assistance reimbursement.

About the Company

The University of Pennsylvania is the largest private employer in Philadelphia, a world-renowned leader in education, research, and innovation, and a historic, Ivy League school consistently ranking among the top 10 universities.
Penn has 12 highly-regarded schools offering diverse educational opportunities, influenced by a distinctive interdisciplinary approach.
Penn has been recognized nationally as an employer, including being named one of America’s Best Large Employers by Forbes in 2023.
The University offers a unique working environment on a beautiful urban campus in Philadelphia, with access to educational, cultural, and recreational activities.
The Perelman School of Medicine is the department/school associated with this position.

Equal Opportunity

The University of Pennsylvania is an equal opportunity employer. Candidates are considered for employment without regard to race, color, sex, sexual orientation, religion, creed, national origin (including shared ancestry or ethnic characteristics), citizenship status, age, disability, veteran status or any class protected under applicable federal, state or local law.