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About the Role
The Bioinformatics for Next Generation Sequencing (BiNGS) Shared Resource at the Tisch Cancer Center is seeking an experienced Bioinformatician II to lead transcriptomics, epigenomics, and multiomics data analysis projects focused on cancer biology. BiNGS aims to accelerate biomedical discovery by providing investigators with state-of-the-art NGS analysis, computational tools, training, and bioinformatics expertise. As a senior member, you will collaborate with investigators to design, execute, interpret, and communicate complex genomic analyses, lead projects from inception to publication, and mentor junior bioinformaticians.
Responsibilities
- Provide scientific and analytical leadership for complex transcriptomics and epigenetics BiNGS projects, translating investigator questions into computational strategies and leading analyses using the Mount Sinai HPC environment.
- Manage multiple collaborative projects simultaneously, including study design, project management, data analysis, interpretation, and presentation of results.
- Integrate internally generated datasets with publicly available resources to identify biologically meaningful patterns and generate new hypotheses.
- Develop publication-quality figures, visualizations, and analytical reports for manuscripts, grant applications, and scientific presentations.
- Evaluate, implement, and benchmark emerging computational methods for multiomic data integration, visualization, and analysis.
- Perform large-scale analyses using the Mount Sinai HPC environment and oversee data management, storage, archiving, and workflow execution.
- Maintain and support cloud-based computational resources, preferably using Amazon Web Services (AWS), including deployment of interactive reports and web-based applications.
Requirements
- M.S. in Bioinformatics, Biomedical Informatics, Computational Biology, or Genomics, or a related field with strong computational and analytical skills and some biology exposure.
- Ph.D in a related field preferred.
- Bachelors degree with additional post-graduate experience considered.
- 2+ years post-graduate experience in a research environment, including the manipulation of large biological datasets.
- Advanced knowledge of genetics and/or statistical analysis software and online resources.
- Experience in programming environments such as MatLab, R statistical package, BioConductor, Perl and C++.
Skills
- Master's degree or PhD in Bioinformatics, Computational Biology, Computer Science, or a related quantitative discipline.
- Proven experience analyzing bulk and single cell epigenetics and transcriptomics datasets (e.g. ATAC-seq, CUT&RUN, ChIP-seq, single-cell ATAC-seq, single-cell RNA-seq and Micro-C).
- Strong programming skills in Python, R, Linux, and Bash.
- Experience using standard genomics software, including Bowtie2, STAR, Cell Ranger, Samtools, MACS2, Seurat, Signac, Cicero, ChromVAR, SCENIC+, and the UCSC Genome Browser.
- Experience working in Linux-based high-performance computing environments with parallel file systems.
- Experience managing analyses and data using Amazon Web Services (AWS) or comparable cloud computing platforms.
- Experience using modern AI-assisted software development tools (e.g., Claude Code, GitHub Copilot, or similar).
- Strong understanding of chromatin biology, transcriptional regulation, and next-generation sequencing technologies.
- Excellent analytical, organizational, communication, and problem-solving skills.
- Demonstrated ability to work independently while collaborating effectively within multidisciplinary research teams.
Location
- New York, NY
Work Type
- Full-time
Experience Level
- 2+ years post-graduate experience
- Senior
Education Level
- Master's degree
- PhD
About the Company
- The Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education.
- Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it.
- Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment.
- The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers.
- Consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and highly ranked in multiple specialties.
- The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding.
- Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally.
Equal Opportunity
- The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws.
- We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law.
- We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported.
- Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization.