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About the Role

Axsome Therapeutics is seeking a Director/Senior Director, HEOR Modeling and Evidence Synthesis to serve as the company’s senior technical expert for health economic modeling and comparative evidence generation. This hands-on role will conceptualize, build, validate, interpret, and communicate fit-for-purpose models supporting marketed products and pipeline assets across rare and prevalent CNS conditions.

Responsibilities

Responsible for end-to-end development of health economic models, from conceptualization and technical specifications through programming, validation, adaptation, reporting, interpretation, and external communication.
Design and develop fit-for-purpose models, including cost-effectiveness and cost-utility models, cost-consequence analyses, budget impact models, decision trees, cohort and patient-level state-transition models, partitioned-survival models, discrete-event simulations, microsimulations, and disease-progression and natural-history models.
Select appropriate modeling approaches reflecting disease characteristics, product maturity, available evidence, stakeholder requirements, and intended use.
Develop transparent model structures, assumptions, inputs, parameter distributions, and validation plans; conduct uncertainty analyses.
Lead internal and external technical review and validation of models; ensure reproducibility, version control, quality control, complete technical documentation, and adherence to good modeling practices.
Partner with HEOR Product Leads to prioritize modeling and evidence-synthesis needs within integrated evidence generation plans and product strategies.
Provide model-based insights to inform evidence generation planning, target product profile assessment, pricing and access strategy, launch readiness, clinical development, and lifecycle management.
Serve as Axsome’s internal technical authority on the Institute for Clinical and Economic Review (ICER) methods, evidence expectations, and economic model critique.
Partner with HEOR Leads to translate complex modeling findings into clear messages and evidence for payer engagement, AMCP and global value dossiers, field medical materials, scientific communications, and internal decision-making.
Establish modeling and evidence-synthesis standards, templates, validation expectations, and reusable technical assets; mentor colleagues and strengthen organizational capability.
Lead or directly conduct systematic literature reviews supporting clinical and economic value assessment.
Conceptualize, conduct, and critically appraise indirect treatment comparisons and formal network meta-analyses using appropriate frequentist or Bayesian methods.
Evaluate network connectivity, transitivity, heterogeneity, inconsistency, effect modifiers, proportional hazards assumptions, and other methodological considerations; design sensitivity and scenario analyses to test robustness.
Partner with HEOR Leads to translate evidence synthesis outputs into economic models, value dossiers, payer evidence, strategic evidence plans, and scientific communications.
Advise HEOR Leads and cross-functional stakeholders on modeling strategy, evidence tradeoffs, uncertainty, methodological limitations, and implications for payer, access, medical, and publication strategies.
Communicate complex methods and findings clearly to technical and non-technical audiences, including executive stakeholders, cross-functional teams, and external collaborators.
Influence without direct authority by building alignment, setting technical standards, and enabling consistent, high-quality evidence generation across products and lifecycle stages.

Requirements

PhD, PharmD, MD, DrPH, or relevant Master’s degree in health economics, economics, operations research, decision science, epidemiology, biostatistics, public health, outcomes research, or a related quantitative discipline.
10+ years of relevant HEOR, health economic modeling, and evidence-synthesis experience in pharmaceutical, biotechnology, medical device, consulting, or academic setting, with substantial experience supporting biopharmaceutical products.
Demonstrated record of independently leading multiple complex economic models across different product types, lifecycle stages, therapeutic areas, and both rare and prevalent conditions.
Demonstrated understanding of the Medicare & Medicaid ecosystem; experience with long-term care evidence, coverage, or decision-making is a plus.
Demonstrated hands-on experience with U.S. ICER assessments, including critical evaluation of ICER economic models and evidence reports and development of analyses or responses supporting manufacturer engagement.
Demonstrated experience conducting systematic literature reviews and formal network meta-analyses, including protocol development, statistical execution, interpretation, and reporting.
Strong track record of peer-reviewed publications and scientific presentations, including authorship of modeling or evidence-synthesis research.
Ability to work on site Monday, Tuesday & Thursday.
Expert knowledge of decision-analytic modeling, simulation methods, survival analysis, uncertainty analysis, model calibration, validation, and good modeling practices.
Advanced proficiency developing transparent, auditable models in Microsoft Excel; proficiency in R and/or other relevant statistical or simulation software strongly preferred.
VBA, Python, TreeAge, or specialized simulation software experience is desirable.
Deep understanding of clinical, epidemiologic, utility, resource-use, cost, and comparative-effectiveness inputs required for model development, including methods for extrapolation and treatment-effect estimation.
Expertise in systematic review methods, indirect comparisons, and network meta-analysis; ability to evaluate study quality, bias, heterogeneity, inconsistency, and applicability to the target decision problem.
Knowledge of payer evidence requirements, AMCP dossiers, value communications, reimbursement and access environments, and relevant modeling and evidence-synthesis guidelines.
Experience designing or conducting analyses using administrative claims and/or electronic health records is a plus.
Excellent writing, presentation, and interpersonal skills, with the ability to translate complex methods, uncertainty, and tradeoffs into actionable recommendations for senior and cross-functional audiences.
Collaborative, adaptable, diplomatic, detail-oriented, and comfortable navigating ambiguity.
Launch and lifecycle-management experience is strongly preferred; neuroscience experience is preferred.

Skills

Health Economic Modeling
Evidence Synthesis
Cost-Effectiveness Modeling
Budget Impact Modeling
Decision Trees
State-Transition Models
Partitioned-Survival Models
Discrete-Event Simulations
Microsimulations
Disease-Progression Models
Natural-History Models
Systematic Literature Reviews
Indirect Treatment Comparisons
Network Meta-Analyses
Microsoft Excel
R
VBA
Python
TreeAge
Statistical Software
Simulation Software
Payer Evidence Requirements
AMCP Dossiers
Value Communications
Reimbursement and Access Environments
Administrative Claims Analysis
Electronic Health Records Analysis

Location

New York City

Work Type

On-site (at least three days per week)

Experience Level

Director/Senior Director
10+ years of relevant HEOR, health economic modeling, and evidence-synthesis experience

Education Level

PhD, PharmD, MD, DrPH, or relevant Master’s degree in health economics, economics, operations research, decision science, epidemiology, biostatistics, public health, outcomes research, or a related quantitative discipline.

Salary/Compensations

$220,000 - $285,000

Benefits

Annual bonus
Significant equity
Generous benefits package

About the Company

Axsome Therapeutics is a biopharmaceutical company leading a new era in the treatment of central nervous system (CNS) conditions.
We deliver scientific breakthroughs by identifying critical gaps in care and develop differentiated products with a focus on novel mechanisms of action that enable meaningful advancements in patient outcomes.
Our industry-leading neuroscience portfolio includes FDA-approved treatments for major depressive disorder, agitation associated with dementia due to Alzheimer’s disease, excessive daytime sleepiness associated with narcolepsy and obstructive sleep apnea, and migraine, as well as multiple novel product candidates addressing a broad range of serious neurological and psychiatric conditions that impact over 150 million people in the United States.
Together, we are on a mission to solve some of the brain’s biggest problems so patients and their loved ones can flourish.

Equal Opportunity

Axsome is committed to equal employment opportunity and providing reasonable accommodations to applicants with physical and/or mental disabilities.
We value and encourage diversity and solicit applications from all qualified applicants without regard to race, color, gender, sex, age, religion, creed, national origin, sexual orientation, gender identity, ancestry, citizenship, marital status, physical or mental disability, medical condition, veteran status, genetic information, or any other characteristic protected by federal, state, or local law.