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About the Role

Mount Sinai Health System is seeking a Specialty Laboratory Technologist (Histocompatibility) to join our Histocompatibility and Immunology Laboratory (HLA Lab). This role is crucial in supporting Solid Organ and Bone Marrow Transplant Programs by performing serological and molecular HLA testing to ensure optimal donor-recipient matching. The ideal candidate is a highly skilled laboratory professional with a strong attention to detail, problem-solving abilities, and commitment to regulatory compliance. This position offers the opportunity to work in a fast-paced, high-volume laboratory that directly impacts patient outcomes.

Responsibilities

Demonstrates the ability to perform clinical/technical/service/administrative tasks.
Performs technical procedures in Immunogenetics as outlined in the policy and procedure manual(s).
Performs periodic/scheduled and as needed maintenance on instrumentation/equipment, maintaining documentation including remedial action for problems encountered.
Performs quality control and calibration procedures when indicated, verifies in laboratory information system, and records on Levy-Jennings charts.
Ensures all required Quality Control and/or calibration procedures are completed by signing out records appropriately.
Maintains all records as per regulatory requirements: card files, patient requisitions, LIS Documentation, statistical data.
Consults with the Supervisor or the Pathologist on all important results, conflicting or out of range results, and notes inadequate volume and/or abnormal appearance of sample.
Reviews all Critical Test results by repeat analysis if necessary, and communicates the same to Nursing Staff/Physician, notifying Supervisor/Pathologist in extreme cases.
Prioritizes work activities to meet established/expected test result turnaround time and notifies Supervisor if unable to perform a test or if it is delayed.
Assists in Inventory Control to assure adequate supplies are available and reagents are stored properly.
Participates in other projects/duties as assigned by the Supervisor/Lab Management.
Takes initiative in resolving instrument related problems and finding alternate options for test processing.
Uses available time to departmental advantage and assists where needed.
Demonstrates the knowledge and skills necessary to provide care, based on physical, psychosocial, educational, safety, and related criteria, appropriate to the age of the patients served in assigned area.
May be required to perform other duties as assigned or perform other duties when necessary.
Participates in the departments performance improvement activities.
Maintains patient/employee confidentiality in the management of information.
Observes the Health Care Systems compliance policies.
Participates in Competency and Proficiency testing programs, reports results back to Supervisor.
Observes all Safety procedures and precautions, including using Personal Protective Equipment and disposing of contaminated waste and samples as specified.
Wears hospital ID badge at all times while on premises.
Perform serological and molecular HLA testing to support solid organ and bone marrow transplantation.
Conduct tests such as HLA typing (based NGS/RT-PCR), crossmatching, antibody screening, and flow cytometry-based assays.
Work closely with transplant coordinators, clinicians, and other healthcare professionals to facilitate timely and accurate test reporting.
Notify the supervisor or clinician of any critical, out-of-range, or conflicting test results.
Ensure proper storage of temperature-sensitive materials, routinely checking laboratory equipment.
Adhere to safety protocols for handling biohazardous samples and chemicals.
Participate in test validation, laboratory research, and development of new testing methodologies.
Stay current with advancements in histocompatibility testing through continuing education and professional development.
Contribute to quality improvement projects that enhance lab performance and efficiency.
Assist in the training and mentorship of new technologists and laboratory personnel.
Engage in proficiency testing programs to ensure competency and skill enhancement.

Requirements

Bachelor’s degree (B.S.) in Medical Technology, Clinical Laboratory Science, Biology, or a related field, meeting NYS Department of Health (DOH) technologist standards.
0–1 year of experience in a clinical laboratory setting, preferably in Histocompatibility, Immunology, or Transplantation Laboratory.
New York State Clinical Laboratory Technologist License (issued by DOH/Office of Professions) or Restricted Technologist License in Histocompatibility required.
Moderate physical activity including standing, bending, lifting (up to 15 lbs.), and typing.
Exposure to infectious and hazardous materials, including blood, tissues, and chemicals.
Ability to handle human tissue samples (e.g., spleen, lymph nodes, blood).
Must comply with biohazard safety protocols and wear personal protective equipment (PPE) as required.
Availability to work on-call hours and flexible shifts as needed by the department.
Compliance with hospital policies, regulatory requirements, and laboratory best practices.

Skills

Histocompatibility
Immunology
Transplantation Laboratory
Serological testing
Molecular HLA testing
HLA typing (NGS/RT-PCR)
Crossmatching
Antibody screening
Flow cytometry-based assays
Quality control
Instrumentation maintenance
Laboratory information system (LIS)
Biohazard safety protocols
Personal Protective Equipment (PPE) usage
Test validation
Laboratory research
New testing methodologies development
Continuing education
Professional development
Quality improvement projects
Mentorship
Proficiency testing

Location

New York metro area

Work Type

Full-time
On-call

Experience Level

0-1 year experience
New graduates encouraged

Education Level

Bachelor's degree in Medical Technology, Clinical Laboratory Science, Biology, or related field
NYS Clinical Laboratory Technologist License or Restricted Technologist License in Histocompatibility

Salary/Compensations

$54.6909 - $67.0585 Hourly

About the Company

The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence.
We share a common dedication to delivering outstanding patient care.
When you join us, you become part of Mount Sinai’s unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare.
We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual.
At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow.
We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well-being of our staff, patients, and organization.
Our leaders are expected to challenge outdated practices, promote a culture of respect, and work toward meaningful improvements that enhance patient care and workplace experiences.
We are dedicated to building a supportive and welcoming environment where everyone has the opportunity to thrive and advance professionally.
Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education.
Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it.
Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment.
The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers.
We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics, top 5 in Cardiology/Heart Surgery, and top 20 in Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology.
New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology.
U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children’s Hospital among the country’s best in several pediatric specialties.
The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges.
Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

Equal Opportunity

The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws.
We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law.
We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported.
Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization.