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About the Role
Y-Trap is seeking a highly motivated and fast-moving Scientist – In Vivo, who will be responsible for the design and hands-on execution of murine in vivo experiments to advance the discovery and development of multifunctional fusion proteins.
Responsibilities
- Independently execute mouse tumor efficacy and PK/PD studies to evaluate the effects of immuno-modulating therapeutics.
- Manage shared space in a contract vivarium, including ordering mice/reagents and liaising with vivarium staff.
- Perform tumor implantation, dosing, blood collection, and tissue harvests; monitor tumor growth, treatment response, and animal health.
- Collaborate with the immunology team, with opportunities to contribute to in vitro assays and immune cell characterization.
Requirements
- Strong oncology in vivo expertise.
- Proficient in tumor implantation, tumor measurement, drug administration (i.p., i.v.), blood collection, and necropsy.
- Detail-oriented and precise with meticulous notes, a detailed schedule of activities, and prompt data recording/sharing.
- Self-driven and resourceful with a mentality to do whatever it takes to get the job done.
- Several years of hands-on mouse work.
- Excited to use skills for hands-on work for the next 1-2 years.
- Experience with surgical tumor models, including performing orthotopic tumor implantation and intrasplenic tumor cell inoculation.
- Experience working with/generating humanized mice using huPBMCs and/or huCD34+ HSCs.
- Experience with adjacent in vitro assays such as tumor cell line culture, tissue dissociation, PK analysis, and flow cytometry.
- Experience with mouse models of inflammation or autoimmune disease.
Skills
- Murine in vivo experiments
- Tumor efficacy studies
- PK/PD studies
- Immuno-modulating therapeutics evaluation
- Vivarium management
- Mouse handling
- Tumor implantation
- Tumor measurement
- Drug administration (i.p., i.v.)
- Blood collection
- Necropsy
- Oncology
- Surgical tumor models
- Orthotopic tumor implantation
- Intrasplenic tumor cell inoculation
- Humanized mice generation
- huPBMC handling
- huCD34+ HSC handling
- Tumor cell line culture
- Tissue dissociation
- PK analysis
- Flow cytometry
- Mouse models of inflammation
- Mouse models of autoimmune disease
Location
- South San Francisco, CA
Work Type
- Full-time
Experience Level
- Senior
- Not entry-level
Benefits
- Competitive salary
- Benefits
- Stock options
About the Company
- Y-Trap is a startup in South San Francisco developing novel multi-specific therapeutics for cancer immunotherapy.
- Y-Trap has utilized its AI-driven engineering platform to develop a portfolio of multi-specific fusion proteins designed to counteract the determinants of tumor-promoting immune cell phenotypes.
- Y-Trap is currently advancing its lead programs into the clinic.