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About the Role
Y-Trap is seeking a highly motivated and fast-moving Scientist – Immunology, responsible for designing and executing in vitro and murine in vivo experiments to advance the discovery and development of multifunctional fusion proteins.
Responsibilities
- Design, execute, and interpret in vitro immunological assays to characterize therapeutic activity and investigate mechanism of action.
- Independently execute mouse tumor efficacy and PK/PD studies, monitoring tumor growth, treatment response, and animal health.
- Characterize immune cells from tumors and other tissues, and integrate in vitro and in vivo findings to guide therapeutic development.
- Manage shared space in a contract vivarium, including ordering mice/reagents and liaising with vivarium staff.
Requirements
- Strong oncology in vivo expertise.
- Proficient in tumor implantation, tumor measurement, drug administration (i.p., i.v.), blood collection, and necropsy.
- Strong expertise in a variety of immunological assays, cell culture and immune cell characterization.
- Comfortable talking about different immune populations, digging into the literature to understand a surprising result, and bringing a new assay online.
- Self-driven and resourceful with a mentality to do whatever it takes to get the job done in a small team with a lot of autonomy.
- Excited to work hands-on both at the bench and in the vivarium.
- Experience with orthotopic tumor implantation and intrasplenic tumor cell inoculation.
- Experience with humanized mouse models using huPBMCs and/or huCD34+ HSCs.
- Experience with in vivo and ex vivo models of inflammation or autoimmune disease.
- Experience with ex vivo culture of immunocompetent tumor fragments / organotypic slices / organoids.
Skills
- In vitro immunological assays
- Murine in vivo experiments
- Mouse tumor efficacy studies
- PK/PD studies
- Flow cytometry
- Cell culture
- Immune cell characterization
Location
- South San Francisco, CA
Work Type
- Full-time
Experience Level
- Senior
- Varying seniority encouraged
Education Level
- PhD in immunology or related field, or equivalent industry experience
Salary/Compensations
- Competitive salary
Benefits
- Stock options
About the Company
- Y-Trap is a startup in South San Francisco developing novel multi-specific therapeutics for cancer immunotherapy.
- Y-Trap has utilized its AI-driven engineering platform to develop a portfolio of multi-specific fusion proteins designed to counteract the determinants of tumor-promoting immune cell phenotypes.
- Y-Trap is currently advancing its lead programs into the clinic.