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About the Role
Develop and execute cell-based assays for validating computational predictions and supporting medicinal chemistry efforts at the interface of disease biology, protein biophysics, and drug screening.
Responsibilities
- Develop and optimize mammalian cell-based assays for disordered protein targets
- Execute phenotypic and reporter-based screening campaigns to validate computational hits
- Characterize compound activity and support structure-activity relationship studies
- Collaborate with computational scientists to integrate experimental data with modeling workflows
- Establish robust assay protocols and quality control metrics
Requirements
- Strong foundation in mammalian cell culture and cellular assay development
- Experience with disease-relevant cellular models
- Ability to troubleshoot complex biological systems and optimize experimental protocols
- Track record of productivity and effective collaboration
Skills
- Mammalian cell culture
- Cellular assay development
- Reporter assays
- High-throughput screening platforms
Location
- Remote
Work Type
- Full-time
Experience Level
- PhD
- Industry experience
Education Level
- PhD in cell and molecular biology with focus on disease models
About the Company
- Pioneering drug discovery for intrinsically disordered proteins—targets that have eluded conventional approaches in neurodegeneration, oncology, and cardiometabolic disease.