Impress employers and recruiters.
Choose from hundreds of resume examples.

Target Resume Now

Tailor your resume to this Senior Scientist/Principal Scientist, Protein Sciences: Analytical & Biophysical Characterizations role.

Rezi rewrites your resume against Soleil Labs, LLC's job description. Free.

Resume score gauge reading 58 out of 100

Don't guess if your resume is good enough.

See how it scores against the Senior Scientist/Principal Scientist, Protein Sciences: Analytical & Biophysical Characterizations posting at Soleil Labs, LLC — free, in seconds.

About the Role

Soleil is seeking an expert, hands-on scientist to lead analytical and biophysical characterization efforts within the Protein Sciences group. This role involves designing, developing, validating, and executing comprehensive developability assessments and analytical characterizations for biologics, serving as the go-to expert for complex analytical challenges and driving technical strategy across programs.

Responsibilities

Design, develop, validate, and execute analytical and biophysical methods (LC-MS, chromatography, thermal/structural assays, immunogenicity assessments) for diverse protein and antibody formats.
Establish robust, fit-for-purpose assays to characterize therapeutic biologics throughout the preclinical pipeline.
Execute experiments with precision, conduct detailed observations, analyze and interpret data rigorously, and deliver results in a timely, concise manner.
Prepare and lead comprehensive developability assessments packages for biologic candidates, evaluating stability, solubility, aggregation, post-translational modifications, manufacturability, immunogenicity potential, and key risk factors.
Serve as technical lead for due diligence and business development contexts, evaluating external analytical data and advising senior decision-makers.
Define analytical strategy across the portfolio in collaboration with research, CMC, and program teams.
Serve as SME for complex analytical and characterization challenges, providing expert guidance to cross-functional teams.
Evaluate emerging analytical technologies for feasibility and performance, guiding adoption to enhance throughput, sensitivity, and risk mitigation.
Mentor junior scientists and collaborate with peers on scientific approaches and best practices.
Manage an experienced scientist as a direct report.
Play a key analytical role in drug candidate selection decisions, advising senior leadership on analytical feasibility and developability risk.
Manage CROs and external collaborations for method development, validation, tech transfer, and analytical support.
Prepare precise technical summaries, protocols, and analytical packages, maintaining rigorous documentation standards.
Contribute to program team discussions as a functional technical lead, communicating effectively across line-functions.

Requirements

Ph.D. or equivalent in a related discipline (e.g., molecular biology, biochemistry, biophysics, analytical chemistry).
5+ years of experience in protein and antibody characterization and developability in an industry setting, preferably startup or biotechnology companies.
Expertise in biophysical and analytical techniques including HPLC, CE, SPR, DSF, DSC, SEC-MALS, LC-MS, and immunogenicity assays.
Solid, hands-on understanding of protein analytical principles, methodologies, and PTMs characterization.
Extensive, hands-on experience in developability studies for antibody therapeutics (monoclonal, bispecific, multi-specific antibodies, fusion proteins, antibody-drug conjugates).
Deep understanding of attributes of protein therapeutic drug candidates and biologics drug discovery process (hit-to-lead, lead optimization, candidate selection).
Demonstrated excellence at troubleshooting complex analytical and characterization challenges.
Strong attention to detail in experimental design and execution.
Excellent oral presentation and written communication skills.
Strong collaborative and mentoring skills.
Flexibility, adaptability, and ability to learn new techniques and technologies.
Familiarity with CMC development process.
Prior experience with managing direct report(s) is preferred.
Experience with protein purification, membrane proteins, and/or multi-specific antibody formats is highly desired.
Prior experience with IND filing is highly desired.

Skills

Analytical method development
Biophysical characterization
LC-MS
Chromatography
Thermal/structural assays
Immunogenicity assessments
Developability assessments
HPLC
CE
SPR
DSF
DSC
SEC-MALS
Protein purification
Troubleshooting
Technical leadership
Mentoring
CRO management
Data analysis
Scientific communication

Location

South San Francisco

Work Type

On-site
Full-time
Lab-based

Experience Level

Senior Scientist
Principal Scientist
5+ years experience

Education Level

Ph.D. or equivalent

Salary/Compensations

$140,000 - $210,000 annually

Benefits

Medical Insurance
Dental Insurance
Vision Insurance
Life Insurance
Short Term Disability
Long Term Disability
Health Savings Account (HSA)
Flexible Spending Accounts (FSA)
401k plan
PTO

About the Company

TCG Labs-Soleil, established in partnership with The Column Group, is pioneering a novel ‘venture capital-biotech’ model.
The company's core mission is to efficiently translate scientific insights into therapeutic solutions for patients facing serious diseases.
This model supports scientific entrepreneurs from the initial idea to clinical proof of concept (PoC) by combining a dedicated fund (TCG Labs) with an independent, evergreen R&D center led by a top-tier scientific team (Soleil).
Together, they create an integrated ecosystem that fosters the development of single-asset portfolio companies, strategically poised for transacting after clinical PoC.

Equal Opportunity

TCG Labs-Soleil is an Equal Opportunity Employer.
We do not discriminate against qualified applicants based upon any protected group status, including but not limited to race, religion, color, creed, sex (including breastfeeding and related conditions), gender identity/gender expression, pregnancy (including childbirth and related conditions), national origin, ancestry, age, marital status, military or veteran status, sexual orientation, genetic information, physical or mental disability or medical condition as defined by applicable equal opportunity laws.
Any request for accommodation can be directed to contact@tcglsoleil.com.