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About the Role
Engitix Therapeutics is a pioneering biotech company dedicated to unlocking extracellular matrix biology to develop transformative therapeutics in fibrosis and oncology. We are seeking an accomplished Scientist to join our Antibody Discovery team and play a hands-on role in the screening and characterisation of antibody candidates across multiple modalities.
Responsibilities
- Design, execute and troubleshoot lab-based binding assays, including ELISA and SPR, to support hit identification and characterisation
- Contribute to antibody discovery and screening campaigns across multiple modalities
- Analyse, interpret and clearly present experimental data to the team and in project meetings
- Proactively identify and troubleshoot technical issues, proposing new approaches where needed
- Keep accurate, well-organised records using electronic lab notebooks in line with good laboratory practice
- Drive smart, automated sample handling
- Work flexibly across projects and priorities as needs evolve
Requirements
- BSc or MSc in a biological subject with relevant lab experience in an academic or biotech setting
- Hands-on experience running ELISA and/or SPR (or other protein-protein interaction methods, e.g. BLI)
- Good working knowledge of antibody discovery and/or antibody drug development concepts: selection, humanisation, Fc-engineering, production, purification and developability profiling
- Comfortable working with, or keen to quickly learn, multiple antibody modalities (e.g. monoclonals, bispecifics, fragments)
- Strong organisational skills and attention to detail, with the ability to manage multiple priorities
- A proactive, adaptable mindset with genuine enthusiasm for working in a biotech environment
- Prior experience working with or managing CROs
- Experience with in vivo campaigns
- Experience/knowledge of cell-based assays (e.g. flow cytometry, Fc effector function assays)
- Exposure to high-throughput screening approaches
- Prior industry, placement, or internship experience in a biotech/pharma setting
Skills
- ELISA
- SPR
- BLI
- Antibody discovery
- Antibody drug development
- Selection
- Humanisation
- Fc-engineering
- Production
- Purification
- Developability profiling
- Monoclonal antibodies
- Bispecific antibodies
- Antibody fragments
- Organisational skills
- Attention to detail
- Proactive mindset
- Adaptable mindset
- Collaboration
- Communication
- CRO management
- In vivo campaigns
- Cell-based assays
- Flow cytometry
- Fc effector function assays
- High-throughput screening
Location
- White City Place, West London
Work Type
- Full-time
Experience Level
- MSc plus a few years in industry
- PhD
Education Level
- BSc
- MSc
Benefits
- Private medical insurance
- Pension
- Bonus
- Employee perks
About the Company
- Engitix is a growing biotech company based in White City Place, West London.
- We are dedicated to developing better therapies for advanced fibrosis and solid tumours by leveraging our pioneering extracellular matrix (ECM) platform.
- Our platform allows the synthesis of realistic in vitro 3D models that serve as tools to transform our ability to identify new targets and biomarkers, determine mechanisms of action and more accurately predict the efficacy of therapeutic candidates.
- Join us today in our mission to create a healthier future for patients with life-threatening diseases such as fibrosis and cancer.