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About the Role
Join Amgen’s mission of serving patients by pioneering the world of biotech in our fight against the world’s toughest diseases. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. Join us and transform the lives of patients while transforming your career.
Responsibilities
- Design and execute biological and/or biophysical experiments to understand the ADME properties of large molecule therapeutics (and non-traditional small molecule therapies) in support of both drug discovery and early development programs.
- Develop assays and technologies to define mechanisms of in vivo clearance and/or biodistribution processes.
- Interpret data and communicate results to project team representatives.
- Maintain electronic laboratory notebooks of results.
- Develop and execute department strategy for drug candidate teams as a PKDM project representative.
Requirements
- Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable]
- Master’s degree and 3 years of related experience
- Bachelor’s degree and 5 years of related experience
- PhD or MS in immunology, cell biology, biochemistry, biophysics, or equivalent.
- 2+ years of protein therapeutics drug discovery and development experience in biotech industry.
- Basic understanding of protein therapeutics pharmacokinetics.
- Expertise in evaluating protein-protein interactions using modern biophysical analytic techniques.
- Expertise in protein biochemistry and/or cell biology techniques, including reagent preparation, assay development, optimization and troubleshooting.
- Experience translating biochemical and biophysical observations and phenomena into relevant cellular and animal-based models with mechanistic insights is desirable.
- Excellent communication and interpersonal skills.
- Ability and interest to learn and deliver results in a fast-paced, demanding environment.
Skills
- ADME properties
- Large molecule therapeutics
- Non-traditional small molecule therapies
- Drug discovery
- Early development programs
- Assay development
- Technology development
- In vivo clearance mechanisms
- Biodistribution processes
- Preclinical ADME
- Bioanalytical techniques
- Data interpretation
- Communication of results
- Electronic laboratory notebook keeping
- Protein therapeutics drug discovery
- Protein therapeutics development
- Protein therapeutics pharmacokinetics
- Protein-protein interactions
- Biophysical analytic techniques
- Protein biochemistry
- Cell biology techniques
- Reagent preparation
- Assay optimization
- Assay troubleshooting
- Biochemical observations
- Biophysical phenomena
- Cellular models
- Animal-based models
- Mechanistic insights
Location
- US
Work Type
- Lab-based
- Flexible work models where possible
Experience Level
- Senior Scientist
- 3 years of related experience (Master's degree)
- 5 years of related experience (Bachelor's degree)
- 2+ years of protein therapeutics drug discovery and development experience
Education Level
- Doctorate degree PhD OR PharmD OR MD
- Master’s degree
- Bachelor’s degree
- PhD or MS in immunology, cell biology, biochemistry, biophysics, or equivalent.
Salary/Compensations
- 143,820.85USD -194,581.15 USD
Benefits
- Comprehensive employee benefits package
- Retirement and Savings Plan with generous company contributions
- Group medical, dental and vision coverage
- Life and disability insurance
- Flexible spending accounts
- Discretionary annual bonus program
- Sales-based incentive plan (for field sales representatives)
- Stock-based long-term incentives
- Award-winning time-off plans
About the Company
- Amgen is a global biotechnology company with a mission to serve patients living with serious illnesses.
- Since 1980, Amgen has pioneered the biotech industry in its fight against the world's toughest diseases.
- Amgen focuses on four therapeutic areas: Oncology, Inflammation, General Medicine, and Rare Disease.
- Amgen has an award-winning culture that is collaborative, innovative, and science-based.
- Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients.
- Together, Amgen competes in the fight against serious disease.
Equal Opportunity
- Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.
- Amgen will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.
- Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.