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About the Role
The Assistant Lead, TCR Discovery, supports the development of a rigorous, high-throughput discovery and preclinical development engine to identify tumor-specific TCRs for downstream analysis, engineering, and translational development.
Responsibilities
- Design and implement end-to-end personalized TCR discovery workflow, including tumor-reactive T cell identification, TCR cloning and characterization, specificity validation, and safety de-risking.
- Design and implement advanced de-risking methods and workflows to assess alloreactivity, unintended HLA interactions, and off-target toxicity risk.
- Interpret and report complex campaigns for TCR identification against known tumor antigens.
- Integrate data across functional potency, specificity, and safety to support go/no-go decisions on specific TCRs.
- Prepare translational packages supporting IND/CTA-enabling preclinical data.
- Collaborate with cross-functional teams to integrate learnings and advance gene therapy initiatives.
- Operate with the highest integrity and ethics, conducting all experiments following lab, department, and college policies and procedures.
- Mentor and train junior scientists and staff, promoting scientific rigor, collaboration, independent thinking, and career advancement.
- Prepare scientific abstracts and articles, publish results in research journals, and present findings at conferences.
Requirements
- A minimum of 8+ years post-PhD experience in academia or industry.
- Prior experience in TCR discovery, complex immune assays, and preclinical development is required.
- Experience working across functional teams.
Skills
- Deep expertise in high-throughput TCR discovery, functional validation, and safety de-risking.
- Ability to work in a fast-paced and milestone-oriented environment.
- Passion for scientific innovation and bridging basic science with translational impact.
- Familiarity with advancing candidates from discovery through preclinical validation to IND enabling.
- Highly organized and detail-oriented with excellent written and verbal communication skills.
Location
- Upper East Side
Work Type
- Full-time
Experience Level
- 8+ years post-PhD experience
Education Level
- PhD in Immunology, Molecular/Cell Biology, Genetic Engineering or related field
Salary/Compensations
- $128,700.00 - $146,100.00
About the Company
- Cornell welcomes students, faculty, and staff with diverse backgrounds from across the globe to pursue world-class education and career opportunities, to further the founding principle of “any person, any study.”
Equal Opportunity
- No person shall be denied employment on the basis of any legally protected status or subjected to prohibited discrimination involving, but not limited to, such factors as race, ethnic or national origin, citizenship and immigration status, color, sex, pregnancy or pregnancy-related conditions, age, creed, religion, arrest and/or conviction record, military or veteran status, sexual orientation, gender expression and/or identity, an individual’s genetic information, domestic violence victim status, familial status, marital status, or any other characteristic protected by applicable federal, state, or local law.
- Cornell University embraces diversity in its workforce and seeks job candidates who will contribute to a climate that supports students, faculty, and staff of all identities and backgrounds.
- We hire based on merit, and encourage people from historically underrepresented and/or marginalized identities to apply.
- Consistent with federal law, Cornell engages in affirmative action in employment for qualified protected veterans as defined in the Vietnam Era Veterans’ Readjustment Assistance Act (VEVRRA).
- We also recognize a lawful preference in employment practices for Native Americans living on or near Indian reservations in accordance with applicable law.