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About the Role
We are seeking a highly motivated Sr. Scientist to lead protein engineering efforts in support of our platform. The successful candidate will design and execute engineering campaigns to improve the activity, stability, and manufacturability of the enzymes at the core of our technology. This is an individual contributor position focused on hands-on technical expertise and scientific leadership.
Responsibilities
- Design and execute protein engineering campaigns to improve enzyme activity, specificity, thermostability, expression, and manufacturability.
- Design and construct mutagenesis and combinatorial libraries, selecting appropriate diversification and selection strategies.
- Build and run high-throughput screening workflows, including plate-based assays, automation, and liquid handling.
- Develop, optimize, and qualify biochemical and biophysical assays to support screening and candidate characterization.
- Lead formulation optimization for engineered proteins, including screening buffers, excipients, and stabilizers.
- Run thermal, freeze-thaw, and accelerated stability studies, and define storage and handling conditions.
- Express and purify recombinant proteins using chromatography techniques on ÄKTA and gravity column systems.
- Assess purity, identity, and quality using standard analytical methods.
- Analyze and interpret screening, characterization, and stability data.
- Maintain rigorous experimental documentation and adhere to SOPs and data integrity standards.
- Contribute to protocol and SOP development as workflows mature.
- Communicate clearly in writing and verbally with cross-functional partners.
- Present scientific findings at team meetings.
- Collaborate closely with molecular biology, protein production, analytical, engineering, and computational colleagues.
Requirements
- Bachelor’s degree with 10+ years, Master’s degree with 7+ years, or PhD with 3+ years of relevant industry or research experience.
- Degree in Biochemistry, Chemical Engineering, Molecular Biology, Protein Science, Biotechnology, or a related life sciences discipline.
- Demonstrated hands-on experience in protein engineering and library design.
- Demonstrated hands-on experience in high-throughput screening of protein variants.
- Demonstrated hands-on experience in assay development and optimization.
- Demonstrated hands-on experience in protein formulation and stability optimization.
- Demonstrated hands-on experience in protein expression and multi-step chromatographic purification.
- Strong written and verbal communication skills, with the ability to present complex data clearly to both technical and cross-functional audiences.
- Proactive team-player mindset, strong attention to detail, and the ability to work independently and prioritize effectively in a fast-paced environment.
- Familiarity with laboratory safety protocols.
- Experience maintaining rigorous scientific documentation.
- Laboratory automation and liquid handling experience applied to screening workflows.
- Proficiency in data analysis and scripting, or familiarity with machine-learning-guided protein design.
- Experience mentoring junior scientists or leading a project workstream as an individual contributor.
- Must be able to move about the laboratory and office environment regularly.
- Must have fine motor skills and steady hands to handle delicate instruments, operate laboratory equipment, pipette accurately, and perform repetitive benchwork with precision.
- Must be able to lift and carry up to 40 pounds occasionally.
- Must have sufficient visual acuity to read small print on labels, instrument displays, and computer monitors.
- Must be able to wear appropriate personal protective equipment (PPE) such as lab coats, gloves, and safety goggles as required.
Skills
- Protein engineering
- Library design
- High-throughput screening
- Assay development
- Assay optimization
- Protein formulation
- Stability optimization
- Protein expression
- Chromatographic purification
- Biochemical assays
- Biophysical assays
- Data analysis
- Scripting
- Machine learning-guided protein design
- Laboratory automation
- Liquid handling
- ÄKTA systems
- Gravity column systems
- Affinity chromatography
- Ion exchange chromatography
- Size exclusion chromatography
- Hydrophobic interaction chromatography
Location
- South San Francisco
Work Type
- Onsite
- Full-time
Experience Level
- Senior Scientist
Education Level
- Bachelor's degree
- Master's degree
- PhD