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About the Role

The OpenAI Foundation is establishing its life sciences program to accelerate progress in curing diseases and enhancing human health. The program will initially concentrate on AI for Alzheimer's, Public Data for Health, and High-Burden Diseases. We are seeking a Program Director, High-Burden Diseases to help build this initiative from its inception. High-Burden Diseases are defined as those causing over 500,000 deaths and/or 25 million DALYs annually, with market failures leading to underinvestment in R&D. The Foundation invests in applying AI and data to advance R&D for preventing and treating these diseases globally. This is a founding position within the Foundation’s Life Sciences and Curing Diseases program, requiring a generalist approach across multiple focus areas. You will shape strategy, evaluate opportunities, engage with external organizations, and support resource deployment. The role is designed for individuals with the flexibility and judgment to navigate diverse scientific, strategic, and grantmaking challenges. Over time, you may continue as a generalist or specialize within the expanding portfolio. This role demands flexibility, thoughtfulness, strategic thinking, and an action-oriented mindset, with comfort in shifting between topics, engaging experts, and translating the mission into actionable recommendations.

Responsibilities

Work closely with the Head of High-Burden Diseases and team members to support strategy, grantmaking execution, and portfolio management.
Source, evaluate, and recommend grants and funding opportunities across various domains within the High-Burden Diseases program.
Research new disease or technology areas to determine Foundation focus and develop investment theses for sourcing and developing grants.
Engage with the external ecosystem, including researchers, nonprofits, startups, academic centers, funders, and potential grantee organizations globally.
Build and maintain relationships with leaders in relevant scientific and health-related fields.
Conduct diligence on organizations, projects, and leaders, assessing scientific merit, execution capability, and potential impact.
Write clear internal recommendations, briefs, and strategy memos to support decision-making.
Identify ecosystem gaps and propose Foundation initiatives, partnerships, or field-building efforts.
Support the creation of new initiatives from concept to launch, including shaping ideas, convening stakeholders, and establishing new efforts.
Potentially assume broader ownership of expanding work areas over time.
Represent the Foundation in external discussions to build credibility, source opportunities, and strengthen the field.

Requirements

10-15+ years of relevant experience preferred.
Relevant experience in areas such as biology, chemistry, translational medicine, drug development, clinical practice, global health, biotechnology, venture or grant investing in life sciences, or related fields.
Ability to engage credibly across a range of scientific and strategic topics, even without being the deepest domain specialist.
Demonstrated ability to evaluate scientific, technical, or organizational opportunities and make strong recommendations.
Experience engaging credibly with external experts, institutions, and senior stakeholders.
Excellent written and verbal communication skills, including synthesizing complex information clearly and persuasively.
Strong strategic judgment combined with a bias toward execution and the ability to move quickly.
Ability to work effectively in a highly ambiguous, evolving environment.
High degree of ownership, discretion, and accountability.
Deep motivation to help accelerate progress in life sciences and contribute to the Foundation’s mission.

Skills

AI for Alzheimer's
Public Data for Health
High-Burden Diseases
Grantmaking
Strategy development
Opportunity evaluation
External engagement
Relationship building
Due diligence
Scientific assessment
Communication
Strategic judgment
Execution
Adaptability
Problem-solving
Global mindset
AI in R&D
Health interventions
Disease diagnosis
Disease prevention
Disease treatment

Location

San Francisco, CA (strongly preferred)

Work Type

Hybrid (3 days in office per week)
Some travel required

Experience Level

10-15+ years of relevant experience preferred

Salary/Compensations

$300,000 to $370,000 USD

About the Company

AI is transforming work, learning, and healthcare, with the potential for significant benefits like faster medical breakthroughs, accelerated scientific discovery, personalized services, new tools for creativity, economic growth, and improved public services.
The Foundation aims to enable AI's use in solving humanity's hardest problems, enhancing human capabilities, and delivering tangible benefits, while proactively addressing emerging challenges and building societal resilience.
The Foundation plans to invest at least $1 billion over the next year in life sciences, curing diseases, jobs and economic impact, AI resilience, and community programs, including contributions to its $25 billion commitment for curing diseases and AI resilience.

Equal Opportunity

We are an equal opportunity employer and do not discriminate on the basis of race, religion, national origin, gender, sexual orientation, age, veteran status, disability or any other legally protected status.
Pursuant to the San Francisco Fair Chance Ordinance, we will consider qualified applicants with arrest and conviction records.