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About the Role

Olema Oncology is seeking a Vice President of Information Technology to lead the global IT function, focusing on strategy, security, operations, and the implementation of new systems and technologies, including cybersecurity and AI capabilities, to support the company's advancement towards product approval and commercial launch.

Responsibilities

Define and execute a multi-year enterprise IT strategy and applications roadmap aligned with business goals.
Set efficient and scalable architecture, integration, cloud, SaaS, data, and technology lifecycle standards.
Establish a strategic and effective IT operating model.
Establish disciplined intake, prioritization, funding, and delivery processes.
Advise the Executive Committee on technology investments, performance, cybersecurity, and risk.
Own IT budgets, vendors, and major implementation partners.
Ensure the reliable operation of Olema's technology environment, including cloud services, networks, identity and access management, endpoints, collaboration platforms, telecommunications, conference-room technology, service desk, and end-user computing.
Ensure technology readiness for new offices, Ireland operations, commercial field teams, and workforce growth.
Own major IT incidents from detection through restoration, executive communication, root-cause analysis, and verified remediation.
Ensure business-critical processes have tested recovery, manual workarounds, and accountable continuity plans.
Establish a senior client relationship model across every function.
Partner with Finance to ensure systems and integrations support accurate, timely close and reporting, budgeting and forecasting, purchasing controls, vendor and expense management, SOX IT general controls, audit evidence, and scalable public-company operations.
Maintain disciplined technology asset and software license management across the full lifecycle.
Develop effective IT reporting standards to communicate network performance, incident trends, resolution times, employee satisfaction, adoption, security, controls, project health, vendor performance, budget, technical debt, and launch readiness.
Set targets for major IT investments, measure benefits following implementation, and use results to guide priorities and funding.
Lead IT-related vendor selection, contract negotiation, governance, performance management, and renewal decisions.
Build and lead a high-performing team of individual contributors, managers, contractors, and managed service providers.
Develop and own the integrated IT commercial readiness plan based on anticipated regulatory approval and launch timelines.
Partner with Commercial and G&A leadership to define and execute the technology and data roadmap for launch.
Support Commercial in identifying the platforms and services required for a successful launch.
Partner with Manufacturing and Supply Chain to support product planning, inventory, distribution, third-party logistics, serialization and traceability, order management, and revenue reporting.
Support launch-critical Medical Affairs and Pharmacovigilance IT capabilities.
Ensure launch-critical IT systems have clear business ownership, requirements, validation or assurance strategies, integrations, support models, training plans, and contingencies.
Lead cross-functional IT readiness from requirements and vendor selection through integration, testing, training, cutover, stabilization, and post-launch support.
Identify critical-path technology risks early and manage dependencies, governance, readiness metrics, mitigation plans, and executive escalation.
Develop and own the company’s cybersecurity strategy and control environment.
Partner with Quality to maintain compliance with GxP, 21 CFR Part 11, SOX, privacy, computer system validation or assurance, data integrity, records retention, and applicable global requirements.
Partner with HR, Legal, Privacy, Quality, and Compliance to address applicable privacy and security obligations.
Oversee business continuity, disaster recovery, backup, incident response, identity and access management, endpoint security, vulnerability management, security monitoring, and third-party risk.
Maintain inspection and audit readiness, ensure critical vendors are appropriately assessed and monitored, and provide clear security, compliance, and risk metrics to executive leadership and the Board.
Apply a risk-based Computer Software Assurance approach to GxP systems.
Define the enterprise data and artificial intelligence strategy across scientific, clinical, commercial, and corporate priorities.
Establish an AI governance process in partnership with Compliance, Legal, and Quality.
Build a secure data and platform foundation for artificial intelligence and measure adoption, time saved, cycle time, quality, cost, value, and risk.
Evaluate emerging technology with technical curiosity and disciplined experimentation.

Requirements

Strong understanding of biotechnology and pharmaceutical processes from development through commercialization.
Deep knowledge of commercial technology and data capabilities required for a United States pharmaceutical launch.
Ability to design and manage a clear company-wide architecture, with rigorous technical reviews, observable services, explicit service-level objectives, thoughtful automation, strong security, and excellent user experience.
Expertise and proven knowledge of the Microsoft/O365 environment and other enterprise applications, architecture, cloud and SaaS platforms, data, cybersecurity, service management, and responsible artificial intelligence.
Knowledge of GxP, 21 CFR Part 11, SOX, privacy, validation, data integrity, and vendor risk management.
Minimum of 15 years of progressive information technology experience, including senior leadership responsibility in a biotechnology or pharmaceutical company.
Demonstrated success in building, leading, and developing high-performing IT teams.
Direct responsibility and accountability for technology and data readiness supporting at least one United States pharmaceutical product launch.
Demonstrated success building commercial and enterprise technology roadmaps and delivering complex platforms, integrations, data services, and operating models.
Experience leading IT operations across multi-site and distributed workforces.
Experience leading cybersecurity, regulated systems, service delivery, data, and artificial intelligence programs with measurable results.
Experience partnering across Commercial, Medical Affairs, Regulatory Affairs, Quality, Pharmacovigilance, Manufacturing and Supply Chain, Finance, Legal, HR to deliver technology solutions.
Experience selecting and implementing enterprise and commercial platforms, integrating third-party systems, and managing complex cross-functional programs and integrations.
Experience operating in a public company environment and supporting SOX, GxP, inspections, and audits.
Proven ability to advise executives and the Board, build teams, manage service providers, negotiate contracts, and control budgets.
Strategic and pragmatic, connecting technology decisions to patient impact, company milestones, compliance, employee experience, and business performance.
Treats internal functions as strategic clients and enterprise systems as products with accountable owners, roadmaps, experience and reliability measures, lifecycle plans, and continuous improvement.
Simplifies through reusable patterns, coherent data and integration design, disciplined configuration, and clear standards while preserving the speed a scaling company requires.
Collaborative and low ego; builds trust, surfaces disagreements early, clarifies ownership, and reaches decisions that optimize enterprise outcomes.
Technically curious and credible, with sustained interest in architecture, data, security, automation, artificial intelligence, and dependable operations.
Decisive and transparent in prioritization, explaining what will be done, what will not, why, and what must change as resources, risks, or dependencies shift.
Cost conscious and value-oriented, with no tolerance for false savings that create fragile systems, poor adoption, control gaps, or recurring work.
Metrics oriented and accountable; defines outcomes, instruments services, measures benefits, learns from incidents, and adjusts investment based on evidence.
Clear and influential with technical teams, employees, functional leaders, executives, vendors, auditors, and the Board.
High integrity, sound judgment, discretion, urgency, and resilience in a fast-paced and regulated environment.
Able to clearly and effectively communicate verbally and in writing with technical teams, business leaders, executive management, and the Board.
Strong commercial orientation and the ability to connect technology decisions to launch milestones, customer needs, compliance requirements, and business performance.
Metrics-oriented, with the discipline to define targets, measure results, and adjust investments based on evidence.
Collaborative and accountable, with the ability to lead through ambiguity and changing priorities.
Impeccable professional ethics, integrity, and discretion.
Committed to providing high levels of employee and internal customer satisfaction through exceptional IT operations.
Analytical thinking with the ability to manage and effectively prioritize competing priorities and adapt to a fast-paced environment within approved budget.

Skills

Microsoft/O365
Enterprise applications
Architecture
Cloud platforms
SaaS platforms
Data management
Cybersecurity
Service management
Artificial intelligence
GxP
21 CFR Part 11
SOX
Privacy regulations
Validation
Data integrity
Vendor risk management
IT operations
Cloud services
Networks
Workplace technology
End-user computing
Managed service providers
Business continuity
Disaster recovery
Incident response
Identity and access management
Endpoint security
Vulnerability management
Security monitoring
Computer Software Assurance
Data strategy
AI governance
Emerging technology evaluation

Location

San Francisco
Boston
Ireland

Work Type

Onsite
Travel

Experience Level

Vice President
Senior leadership
15+ years of progressive information technology experience

Education Level

Bachelor's degree required
Advanced degree in business, information technology, science, or a related discipline strongly preferred

Salary/Compensations

$335,000 - $365,000 annually

Benefits

Equity
Bonus
Competitive compensation and benefits package
Open, flexible, and friendly work environment
Platform to develop long-term careers

About the Company

Olema Oncology is a clinical-stage biopharmaceutical company committed to transforming the standard of care and improving outcomes for patients living with breast cancer and beyond.
Aspiring to transform the metastatic treatment paradigm is an ambitious endeavor that requires a resolute approach to developing better therapies and a passionate team dedicated to helping the patients we serve feel better, longer.
We possess a deep commitment to our shared purpose, the sustained pursuit of excellence, cultivating the courage required to advance our programs, drive to succeed, and a collective capacity for adaptability through learning, growth, and evolution.
Team Olema is made up of nimble self-starters who bring consistency in their quest for the extraordinary every single day.

Equal Opportunity

We provide equal opportunity to all employees and applicants for employment and believe that great ideas and discoveries come from a mix of expertise, background, and experience.
Olema is building a culture where the value of difference is celebrated.