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About the Role
This role involves analyzing, interpreting, and reporting on molecular diagnostic tests and screening results, including genome sequencing for Constitutional Genomics, carrier screening, and Oncology assays. The individual will contribute to new clinical research, assay development, and improving variant filtering and prioritization infrastructure for clinical reporting within a state-of-the-art clinical genomics laboratory.
Responsibilities
- Identify, annotate, and investigate the clinical significance of genetic variants found in NGS-based molecular assays for undiagnosed genetic diseases, carrier screening, or tumor sequencing.
- Interpret and sign out reports for clinical genome sequencing from various research and clinical projects.
- Collaborate with Senior Director/lab leadership to develop and validate new NGS-based tests and translational research projects.
- Assist in creating an efficient and scalable infrastructure for a high-volume clinical testing laboratory.
- Co-lead efforts to integrate genome sequencing into medical practice.
- Mentor junior team members.
- Create and disseminate precision medicine knowledge of variant-disease associations in the context of genetic disorders.
- Improve the existing infrastructure of variant filtering and prioritization for clinical reporting.
- Participate in educational activities in the Clinical Laboratory.
- Communicate effectively and explain test results to ordering providers, recommending additional testing.
Requirements
- PhD or MD in biology, genetics, biochemistry, or a related field.
- ABMGG Board certified in Clinical Molecular Genetics and Genomics, or Laboratory Genetics and Genomics, or Board certified in Molecular Genomic Pathology.
- At least 4 years of post-board-certification experience in interpretation and reporting of Exome or Genome Sequencing data and/or large-scale carrier screening (Associate Director level).
- At least 6 years of post-board-certification experience in interpretation and reporting of Exome or Genome Sequencing data and/or large-scale carrier screening (Director level).
- Prior experience in a high-volume molecular diagnostic/clinical laboratory.
- Proven track record of hands-on experience in Exome/Genome Sequencing.
- Experience establishing, validating, and/or analyzing large-scale carrier screening programs is preferred.
- Experience with oncology molecular testing, including minimal residual disease (MRD) testing, is preferred.
- New York State Certificate of Qualification in genetic testing or Oncology Molecular and Cellular Tumor Markers required.
- ABMGG Board certified required.
- Ability to thrive in a fast-paced, rapidly changing, start-up like environment.
- Experience with genetic variant classification per ACMG/GlinGen guidelines and/or somatic variant classification per AMP guidelines.
- Knowledge of phenotype ontologies.
- Self-motivated and capable of analyzing and solving complex problems through innovative thought and experience.
- Excellent verbal and written communication skills and organizational skills.
Skills
- Analysis of molecular diagnostic tests
- Interpretation of molecular diagnostic tests
- Reporting of molecular diagnostic tests
- Genome sequencing
- Constitutional Genomics
- Carrier screening
- Oncology assays
- Minimal Residual Disease (MRD) testing
- Clinical research
- Assay development
- Variant filtering
- Variant prioritization
- NGS-based molecular assays
- Undiagnosed genetic diseases
- Tumor sequencing
- Precision medicine
- Variant-disease associations
- Genetic disorders
- Genetic variant classification (ACMG/GlinGen)
- Somatic variant classification (AMP)
- Phenotype ontologies
- Communication
- Collaboration
- Teamwork
- Adaptability
- Innovation
- Problem-solving
Location
- Lower Manhattan
Work Type
- Exempt
- Full-time
Experience Level
- Associate Director
- Director
Education Level
- PhD or MD in biology, genetics, biochemistry, or a related field
- ABMGG Board certified in Clinical Molecular Genetics and Genomics
- ABMGG Board certified in Laboratory Genetics and Genomics
- Board certified in Molecular Genomic Pathology
- New York State Certificate of Qualification in genetic testing
- New York State Certificate of Qualification in Oncology Molecular and Cellular Tumor Markers
Salary/Compensations
- $177,000-$250,000 per year
Benefits
- Medical/Dental/Vision for employees & dependent(s)
- Vacation
- Holidays
- Sick leave
- Other Leave
- Paid winter break
- 401(k) match
- Life Insurance
- Flexible Spending Accounts
- Employee Tuition Reimbursement
- Employee Assistance Program
About the Company
- The New York Genome Center (NYGC) is an independent, nonprofit, academic research organization dedicated to advancing genomic research.
- NYGC scientists and staff are furthering new approaches to diagnosing and treating neurological diseases and cancer through their unique capabilities in whole genome sequencing, RNA sequencing, state-of-the-art analytics, and the development of genomic tools.
- NYGC concentrates specifically on disease-based research in neuropsychiatric disease (autism, schizophrenia, bipolar), neurodegenerative disease (ALS, Alzheimer’s, Parkinson’s, Huntington’s), and cancer.
- Located in Lower Manhattan, the New York Genome Center was founded by and remains closely affiliated with twelve leading academic medical centers and research universities in the New York region and beyond, engaging in research projects with and for these institutions.
- Essential to our collaborative work is an outstanding faculty, whose members typically hold a joint appointment at NYGC and a partner university. They support our scientific mission by conducting independent research in areas of mutual interest to us and the wider scientific community.
Equal Opportunity
- We are committed to fostering a workplace environment that is welcoming and fair to all, ensuring that every employee has the opportunity to thrive.
- We believe that bringing together individuals with diverse backgrounds, experiences, and perspectives leads to greater collaboration, innovation, and discovery.
- Valuing and supporting each employee in reaching their full potential strengthens our organization and enhances our collective success.
- We recognize that creating an environment where all employees feel valued and included requires sustained effort and dedication from the entire organization.
- The New York Genome Center is a VEVRAA Federal Contractor.
- All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, creed, color, gender, religion, national origin, sexual orientation, age, disability, genetic predisposition or carrier status, protected veteran or military status, domestic violence victim status, partnership status, caregiver status, alienage or citizenship status, marital status, or any other characteristic protected by applicable law.
- NYGC takes affirmative action in support of its policy to hire and advance in employment individuals who are protected veterans and individuals with disabilities.