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About the Role
Precision Neuroscience is developing a next-generation brain-computer interface (BCI) to aid individuals with neurological conditions. Our initial product, Layer 7, aims to enable people with severe paralysis to control digital devices using their thoughts. We are seeking a Staff Neuroscientist, Neural Biomarkers to establish and validate biomarkers from human cortical recordings, building a robust program around them. This founding scientist role involves study design, statistical analysis planning, data analysis, and representing scientific findings to partners. As the program expands, the role will include hiring and leading a team.
Responsibilities
- Design prospective human studies within the constraints of intraoperative recording.
- Author a statistical analysis plan for each study before data collection begins.
- Identify and handle confounds inherent to intraoperative data.
- Distinguish exploratory from confirmatory findings in all reporting.
- Define data collection requirements for biomarker hypotheses.
- Perform full analysis from raw high-density cortical recordings to reported results.
- Develop candidate biomarkers from recordings and characterize their time course.
- Establish measurement properties as a prerequisite to claims of drug effect.
- Select and apply statistical methods, report effect sizes, and test robustness.
- Implement analyses as versioned, tested, reproducible code.
- Serve as Precision’s scientific representative to pharmaceutical and biotechnology partners.
- Evaluate therapeutic program fit for an electrophysiological biomarker approach.
- Represent the strength and limits of the evidence accurately.
- Develop the evidentiary strategy for Precision’s biomarkers.
- Act as the scientific bridge between clinical, machine learning, and product teams.
- Publish and present externally, and author technical reports for partners.
- Hire and mentor scientists and analysts on the biomarker program.
Requirements
- PhD in neuroscience, biomedical engineering, biostatistics, clinical pharmacology, or a closely related quantitative field.
- Demonstrated ownership of a human research program.
- Advanced statistics knowledge.
- Hands-on experience analyzing human neural time-series data.
- Strong coding skills in Python, including fluency with modern AI coding tools.
- Biomarker development experience in a biopharmaceutical context.
- Working knowledge of CNS drug development.
- Strong scientific communication skills.
- Comfort with ambiguity, small datasets, and fast iteration.
Skills
- Intracranial or scalp electrophysiology (ECoG, stereo-EEG, LFP, or quantitative EEG) strongly preferred.
- Modern AI coding tools (e.g., Cursor, Claude Code).
- Maintainable, tested code contribution.
- AI-assisted engineering environment.
- Pharmacodynamic, response, or target engagement biomarkers.
- Early-phase study design.
- Exploratory endpoints.
- Go/no-go decision making.
- Scientific communication.
- Credibility and composure.
- Ambiguity.
- Small datasets.
- Fast iteration.
Location
- New York
- Santa Clara
Work Type
- Onsite
Experience Level
- 5+ years of post-PhD experience (Strong Plus)
Education Level
- PhD
About the Company
- Precision Neuroscience is building a next-generation brain–computer interface (BCI) to heal and empower millions of people living with neurological conditions.
- Our first product, Layer 7, is designed to help people with severe paralysis operate digital devices using only their thoughts—opening up new possibilities for daily life.
- Our team brings together experts in neurosurgery, AI and machine learning, microfabrication, electrical engineering, clinical science, and more.
- We combine deep technical rigor with a people-first mindset to turn breakthrough research into real-world medical solutions.
- As a Precision employee, you’ll join one of the fastest-moving and best-capitalized companies in the emerging field of brain–computer interfaces.
- Since our founding in 2021, we have raised more than $180 million, advanced our technology through validation, and initiated human trials with leading hospitals across the country.
- Our Values: We build for human impact, measuring progress by the lives our work can change. We do no harm, holding ourselves to the highest standards of safety, integrity, and responsibility. We innovate with urgency because the stakes are high and our users can’t wait. We bring sharp minds, open ears, pairing expertise with curiosity, humility, and respect. And we lead the way, taking ownership of our work and helping to shape the future of our field.
Equal Opportunity
- Diverse workforces create the best culture, company, and products. We at Precision are committed to an inclusive culture that celebrates the uniqueness and contributions of everyone.
- As an equal opportunity employer, Precision does not discriminate on the basis of sex, race, religion, national origin, disability status, protected veteran status, or any other characteristic protected by law.